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Spc25 Gene Detail
Summary
  • Symbol
    Spc25
  • Name
    SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)
  • Synonyms
    2600017H08Rik, 2610205L13Rik, Spbc25
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913692
    NCBI Gene: 66442
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:69024239-69036538 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 39.64 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    568 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913692
 protein coding gene Chr2:69009753-69036583 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025795
 protein coding gene Chr2:69126080-69139636 (-)
A/J MGP_AJ_G0025772
 protein coding gene Chr2:66468173-66480963 (-)
AKR/J MGP_AKRJ_G0025741
 protein coding gene Chr2:68260185-68277158 (-)
BALB/cJ MGP_BALBcJ_G0025767
 protein coding gene Chr2:66646384-66660209 (-)
C3H/HeJ MGP_C3HHeJ_G0025527
 protein coding gene Chr2:68487340-68502617 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026214
 protein coding gene Chr2:71220734-71234272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023617
 protein coding gene Chr2:63710766-63721879 (-)
CAST/EiJ MGP_CASTEiJ_G0024991
 protein coding gene Chr2:68588378-68602599 (-)
CBA/J MGP_CBAJ_G0025507
 protein coding gene Chr2:73815300-73830081 (-)
DBA/2J MGP_DBA2J_G0025638
 protein coding gene Chr2:66112330-66124600 (-)
FVB/NJ MGP_FVBNJ_G0025601
 protein coding gene Chr2:65482664-65499916 (-)
LP/J MGP_LPJ_G0025727
 protein coding gene Chr2:68988802-69003256 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025630
 protein coding gene Chr2:75882797-75896736 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026271
 protein coding gene Chr2:68344930-68357743 (-)
PWK/PhJ MGP_PWKPhJ_G0024732
 protein coding gene Chr2:65941576-65954054 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024539
 protein coding gene Chr2:68575566-68590663 (-)
WSB/EiJ MGP_WSBEiJ_G0025059
 protein coding gene Chr2:68766905-68780429 (-)



Homology
more
  • Human Ortholog
    SPC25, SPC25 component of NDC80 kinetochore complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPC25, SPC25 component of NDC80 kinetochore complex
  • Synonyms
    AD024, hSpc25, SPBC25
  • Links
    NCBI Gene ID: 57405
    neXtProt AC: NX_Q9HBM1
    UniProt: Q9HBM1

  • Chr Location
    2q24.3; chr2:168834132-168913371 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    55
  • cDNA Data
    13
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005233 Ensembl Gene Model | MGI Sequence Detail 12300 C57BL/6J ±  kb
transcript ENSMUST00000005365 Ensembl | MGI Sequence Detail 1352 Not Applicable  
polypeptide ENSMUSP00000005365 Ensembl | MGI Sequence Detail 226 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919740
References
more
  • Summaries
    All 49
    Developmental Gene Expression 9
    Gene Ontology 9
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory