Tnfaip8l1 MGI Mouse Gene Detail - MGI:1913693 - tumor necrosis factor, alpha-induced protein 8-like 1

Symbol

Tnfaip8l1
Name

tumor necrosis factor, alpha-induced protein 8-like 1
Synonyms

2600017J23Rik

Feature Type

protein coding gene
IDs

MGI:1913693
NCBI Gene: 66443
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr17:56469477-56480955 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 29.19 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

399 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913693	protein coding gene	Chr17:56469439-56491249 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023916	protein coding gene	Chr17:57815869-57828499 (+)
A/J	MGP_AJ_G0023875	protein coding gene	Chr17:56252452-56263924 (+)
AKR/J	MGP_AKRJ_G0023845	protein coding gene	Chr17:56925625-56937004 (+)
BALB/cJ	MGP_BALBcJ_G0023877	protein coding gene	Chr17:56076382-56088023 (+)
C3H/HeJ	MGP_C3HHeJ_G0023640	protein coding gene	Chr17:57637499-57648956 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024321	protein coding gene	Chr17:60094568-60105972 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021768	protein coding gene	Chr17:52750056-52761404 (+)
CAST/EiJ	MGP_CASTEiJ_G0023123	protein coding gene	Chr17:57948153-57959588 (+)
CBA/J	MGP_CBAJ_G0023617	protein coding gene	Chr17:62395005-62406752 (+)
DBA/2J	MGP_DBA2J_G0023745	protein coding gene	Chr17:54967992-54979847 (+)
FVB/NJ	MGP_FVBNJ_G0023711	protein coding gene	Chr17:54491179-54502636 (+)
LP/J	MGP_LPJ_G0023825	protein coding gene	Chr17:58516151-58527872 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023738	protein coding gene	Chr17:61944743-61956139 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024366	protein coding gene	Chr17:57301379-57315889 (+)
PWK/PhJ	MGP_PWKPhJ_G0022868	protein coding gene	Chr17:54315471-54327977 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022680	protein coding gene	Chr17:54067699-54083377 (+)
WSB/EiJ	MGP_WSBEiJ_G0023187	protein coding gene	Chr17:57914017-57926711 (+)

Human Ortholog

TNFAIP8L1, TNF alpha induced protein 8 like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TNFAIP8L1, TNF alpha induced protein 8 like 1
Synonyms

TIPE1
Links

HGNC:28279

NCBI Gene ID: 126282

neXtProt AC: NX_Q8WVP5

UniProt: Q8WVP5
Chr Location

19p13.3; chr19:4639516-4655568 (+) GRCh38

MGI Vertebrate Homology

Tnfaip8l1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TNFAIP8L1
Gene Tree

Tnfaip8l1

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotypes from multigenic genotypes
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

6
Targeted

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice exhibit increased susceptibility to induced colitis.

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

33

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tnfaip8l1

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All Sequences

40
RefSeq

6
UniProt

1
CCDS

CCDS28897.1

Ensembl

ENSMUSG00000044469 (Evidence)
NCBI Gene

66443

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044469	Ensembl Gene Model \| MGI Sequence Detail	11479	C57BL/6J	± kb
transcript	ENSMUST00000077788	Ensembl \| MGI Sequence Detail	2379	Not Applicable
polypeptide	ENSMUSP00000076961	Ensembl \| MGI Sequence Detail	186	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000016477 tumor necrosis factor alpha-induced protein 8-like protein 1

(term hierarchy)
InterPro Domains

IPR008477 Tumor necrosis factor alpha-induced protein 8-like

IPR038355 Tumor necrosis factor alpha-induced protein 8-like superfamily

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All nucleic 33

cDNA 33

Microarray probesets 3

Summaries

All 33

Gene Ontology 5

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tnfaip8l1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr145287	Chr17:56469486-56469549 (+)	41 bp
Tssr145288	Chr17:56469552-56469567 (+)	83 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24