Rps21 MGI Mouse Gene Detail - MGI:1913731

Symbol

Rps21
Name

ribosomal protein S21
Synonyms

1810049N11Rik, 2410030A14Rik

Feature Type

protein coding gene
IDs

MGI:1913731
NCBI Gene: 66481
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr2:179899172-179900237 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 102.78 cM
Mapping Data

1 experiment

SNPs within 2kb

135 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913731	protein coding gene	Chr2:179899170-179900238 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026990	protein coding gene	Chr2:186769660-186773555 (+)
A/J	MGP_AJ_G0026956	protein coding gene	Chr2:179094205-179096223 (+)
AKR/J	MGP_AKRJ_G0026926	protein coding gene	Chr2:184459471-184460539 (+)
BALB/cJ	MGP_BALBcJ_G0026965	protein coding gene	Chr2:179556743-179557811 (+)
C3H/HeJ	MGP_C3HHeJ_G0026706	protein coding gene	Chr2:184806450-184807518 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027411	protein coding gene	Chr2:192160788-192161856 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0026165	protein coding gene	Chr2:183055002-183056071 (+)
CBA/J	MGP_CBAJ_G0026683	protein coding gene	Chr2:199157132-199158200 (+)
DBA/2J	MGP_DBA2J_G0026821	protein coding gene	Chr2:178196236-178197304 (+)
FVB/NJ	MGP_FVBNJ_G0026787	protein coding gene	Chr2:176800940-176802010 (+)
LP/J	MGP_LPJ_G0026922	protein coding gene	Chr2:186766537-186767605 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026806	protein coding gene	Chr2:201769183-201770251 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027470	protein coding gene	Chr2:184418386-184419454 (+)
PWK/PhJ	MGP_PWKPhJ_G0025901	protein coding gene	Chr2:175705083-175706161 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025701	protein coding gene	Chr2:180915847-180916907 (+)
WSB/EiJ	MGP_WSBEiJ_G0026237	protein coding gene	Chr2:185387096-185388167 (+)

Human Ortholog

RPS21, ribosomal protein S21

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RPS21, ribosomal protein S21
Synonyms

eS21, HLDF, S21
Links

HGNC:10409

NCBI Gene ID: 6227

neXtProt AC: NX_P63220

UniProt: P63220
Chr Location

20q13.33; chr20:62387103-62388520 (+) GRCh38

MGI Vertebrate Homology

Rps21 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: RPS21
Protein SuperFamily

Ribosomal_S21e
Gene Tree

Rps21

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Phenotype Summary

7 phenotypes from 2 alleles in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

33
Endonuclease-mediated

2
Gene trapped

28
Targeted

3
Incidental Mutations

CvDC
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice heterozygous for a null allele exhibit reduced growth, premature death, and impaired male fertility.

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All GO Annotations

22
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

720
Tissues

8
cDNA Data

13
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rps21

ZFIN rps21

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All Sequences

54
RefSeq

12
UniProt

1
CCDS

CCDS38376.1

Ensembl

ENSMUSG00000039001 (Evidence)
NCBI Gene

66481

			Length	Strain/Species	Flank
genomic	66481	NCBI Gene Model \| MGI Sequence Detail	1066	C57BL/6J	± kb
transcript	NM_001355516	RefSeq \| MGI Sequence Detail	494	C57BL/6
polypeptide	Q9CQR2	UniProt \| EBI \| MGI Sequence Detail	83	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000014265 small ribosomal subunit protein eS21

(term hierarchy)
PDB

7CPU, 7CPV, 7LS1, 7LS2
InterPro Domains

IPR001931 Small ribosomal subunit protein eS21

IPR018279 Small ribosomal subunit protein eS21, conserved site

IPR038579 Small ribosomal subunit protein eS21 superfamily
GlyGen

Q9CQR2 1 site, 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 14

Primer pair 3

Microarray probesets 6

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MGI:1923769

Summaries

All 36

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:333015 Li H, et al., A male germ-cell-specific ribosome controls male fertility. Nature. 2022 Dec;612(7941):725-731

TSS for Rps21:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr22216	Chr2:179899166-179899189 (+)	6 bp
Tssr22217	Chr2:179899198-179899221 (+)	38 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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