Lamtor1 MGI Mouse Gene Detail - MGI:1913758 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Symbol

Lamtor1
Name

late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Synonyms

2400001E08Rik, p18

Feature Type

protein coding gene
IDs

MGI:1913758
NCBI Gene: 66508
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:101555044-101561110 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.68 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

156 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913758	protein coding gene	Chr7:101555044-101575882 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032593	protein coding gene	Chr7:104921857-104946121 (+)
A/J	MGP_AJ_G0032569	protein coding gene	Chr7:102248681-102271303 (+)
AKR/J	MGP_AKRJ_G0032505	protein coding gene	Chr7:104696131-104719199 (+)
BALB/cJ	MGP_BALBcJ_G0032580	protein coding gene	Chr7:101948312-101969115 (+)
C3H/HeJ	MGP_C3HHeJ_G0032294	protein coding gene	Chr7:105070102-105091116 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033077	protein coding gene	Chr7:108874052-108909808 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030071	protein coding gene	Chr7:104612790-104635351 (+)
CAST/EiJ	MGP_CASTEiJ_G0031620	protein coding gene	Chr7:96626525-96650053 (+)
CBA/J	MGP_CBAJ_G0032260	protein coding gene	Chr7:112643869-112672135 (+)
DBA/2J	MGP_DBA2J_G0032412	protein coding gene	Chr7:100580239-100602272 (+)
FVB/NJ	MGP_FVBNJ_G0032368	protein coding gene	Chr7:100359727-100382938 (+)
LP/J	MGP_LPJ_G0032501	protein coding gene	Chr7:106238899-106264406 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032402	protein coding gene	Chr7:113972940-113996904 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033099	protein coding gene	Chr7:103966672-103991766 (+)
PWK/PhJ	MGP_PWKPhJ_G0031338	protein coding gene	Chr7:93692468-93714047 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031182	protein coding gene	Chr7:91265114-91285705 (+)
WSB/EiJ	MGP_WSBEiJ_G0031737	protein coding gene	Chr7:104653837-104680784 (+)

Human Ortholog

LAMTOR1, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMTOR1, late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
Synonyms

C11orf59, p18, p27RF-Rho, PDRO, Ragulator1
Links

HGNC:26068

NCBI Gene ID: 55004

neXtProt AC: NX_Q6IAA8

UniProt: Q6IAA8
Chr Location

11q13.4; chr11:72085895-72103297 (-) GRCh38

MGI Vertebrate Homology

Lamtor1 stringent orthology
1 human;1 mouse;2 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMTOR1
Gene Tree

Lamtor1

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
36 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

39
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

28
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Lamtor1
Incidental Mutations

CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit growth arrest and lethality at E7 and abnormal visceral endoderm with abnormal endosome-like organelles and small lysosomes.

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All GO Annotations

66
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

861
Tissues

60
cDNA Data

11
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lamtor1

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All Sequences

46
RefSeq

2
UniProt

2
CCDS

CCDS21519.1

Ensembl

ENSMUSG00000030842 (Evidence)
NCBI Gene

66508

			Length	Strain/Species	Flank
genomic	66508	NCBI Gene Model \| MGI Sequence Detail	6067	C57BL/6J	± kb
transcript	NM_025605	RefSeq \| MGI Sequence Detail	1201	C57BL/6
polypeptide	Q9CQ22	UniProt \| EBI \| MGI Sequence Detail	161	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000030559 ragulator complex protein LAMTOR1

(term hierarchy)
InterPro Domains

IPR028209 LAMTOR1/MEH1

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 6

Summaries

All 69

Developmental Gene Expression 3

Gene Ontology 12

Phenotypes 36
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:358517 Li M, et al., AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine. Cell Res. 2024 Oct;34(10):683-706

TSS for Lamtor1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68283	Chr7:101555117-101555199 (+)	114 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24