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Chtop Gene Detail
Summary
  • Symbol
    Chtop
  • Name
    chromatin target of PRMT1
  • Synonyms
    2500003M10Rik, Fop, friend of Prmt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913761
    NCBI Gene: 66511
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:90406263-90416805 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.24 cM, cytoband F2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913761
 protein coding gene Chr3:90405846-90417400 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027467
 protein coding gene Chr3:90819520-90832219 (-)
A/J MGP_AJ_G0027431
 protein coding gene Chr3:87791145-87802311 (-)
AKR/J MGP_AKRJ_G0027396
 protein coding gene Chr3:89951577-89963387 (-)
BALB/cJ MGP_BALBcJ_G0027440
 protein coding gene Chr3:87747855-87757397 (-)
C3H/HeJ MGP_C3HHeJ_G0027182
 protein coding gene Chr3:90113815-90125003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027886
 protein coding gene Chr3:94223972-94236111 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025239
 protein coding gene Chr3:83290451-83299876 (-)
CAST/EiJ MGP_CASTEiJ_G0026628
 protein coding gene Chr3:90504721-90517628 (-)
CBA/J MGP_CBAJ_G0027157
 protein coding gene Chr3:97441968-97453581 (-)
DBA/2J MGP_DBA2J_G0027294
 protein coding gene Chr3:87155956-87168426 (-)
FVB/NJ MGP_FVBNJ_G0027262
 protein coding gene Chr3:85492610-85502566 (-)
LP/J MGP_LPJ_G0027403
 protein coding gene Chr3:91877987-91889229 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027283
 protein coding gene Chr3:103673373-103685636 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027945
 protein coding gene Chr3:89701337-89711926 (-)
PWK/PhJ MGP_PWKPhJ_G0026362
 protein coding gene Chr3:87052681-87063918 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026182
 protein coding gene Chr3:88873837-88884482 (-)
WSB/EiJ MGP_WSBEiJ_G0026710
 protein coding gene Chr3:90105890-90116724 (-)



Homology
more
  • Human Ortholog
    CHTOP, chromatin target of PRMT1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CHTOP, chromatin target of PRMT1
  • Synonyms
    C10orf77, C1orf77, FL-SRAG, FOP, pp7704, SRAG, SRAG-3, SRAG-5
  • Links
    NCBI Gene ID: 26097
    neXtProt AC: NX_Q9Y3Y2
    UniProt: Q9Y3Y2

  • Chr Location
    1q21.3; chr1:153633982-153646306 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    100 phenotypes from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a hypocellular placenta, abnormal placental labyrinth vasculature morphology, abnormal spongiotrophoblast inclusions, double outlet right ventricle, and partial lethality throughout fetal growth and development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    12
  • cDNA Data
    24
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001017 Ensembl Gene Model | MGI Sequence Detail 10543 C57BL/6J ±  kb
    transcript ENSMUST00000249613 Ensembl | MGI Sequence Detail 2012 Not Applicable  
    polypeptide ENSMUSP00000159822 Ensembl | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 24

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140083
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 7
      Phenotypes 21
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:350444 Martinez-Mayer J, et al., Knockout mice with pituitary malformations help identify human cases of hypopituitarism. Genome Med. 2024 May 31;16(1):75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory