Cul7 MGI Mouse Gene Detail - MGI:1913765

Symbol

Cul7
Name

cullin 7
Synonyms

2510004L20Rik, C230011P08Rik, p185, p193

Feature Type

protein coding gene
IDs

MGI:1913765
NCBI Gene: 66515
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr17:46961264-46975290 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 22.90 cM
Mapping Data

2 experiments

SNPs within 2kb

391 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913765	protein coding gene	Chr17:46961263-46975290 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0023824	protein coding gene	Chr17:47727598-47743343 (+)
A/J	MGP_AJ_G0023782	protein coding gene	Chr17:46582002-46596037 (+)
AKR/J	MGP_AKRJ_G0023753	protein coding gene	Chr17:46925566-46940545 (+)
BALB/cJ	MGP_BALBcJ_G0023786	protein coding gene	Chr17:46482791-46497362 (+)
C3H/HeJ	MGP_C3HHeJ_G0023549	protein coding gene	Chr17:47671148-47685215 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0024229	protein coding gene	Chr17:49777658-49794025 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021679	protein coding gene	Chr17:43363992-43378122 (+)
CAST/EiJ	MGP_CASTEiJ_G0023031	protein coding gene	Chr17:47755097-47769535 (+)
CBA/J	MGP_CBAJ_G0023526	protein coding gene	Chr17:51571616-51585515 (+)
DBA/2J	MGP_DBA2J_G0023652	protein coding gene	Chr17:45352840-45366853 (+)
FVB/NJ	MGP_FVBNJ_G0023619	protein coding gene	Chr17:44974888-44990438 (+)
LP/J	MGP_LPJ_G0023733	protein coding gene	Chr17:48407924-48421880 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0023648	protein coding gene	Chr17:51117036-51132058 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0024274	protein coding gene	Chr17:47279749-47294516 (+)
PWK/PhJ	MGP_PWKPhJ_G0022776	protein coding gene	Chr17:44693208-44707427 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0022591	protein coding gene	Chr17:44147706-44163966 (+)
WSB/EiJ	MGP_WSBEiJ_G0023096	protein coding gene	Chr17:47835869-47849810 (+)

Human Ortholog

CUL7, cullin 7

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CUL7, cullin 7
Synonyms

3M1, CUL-7, dJ20C7.5, KIAA0076
Links

HGNC:21024

NCBI Gene ID: 9820

neXtProt AC: NX_Q14999

UniProt: Q14999
Chr Location

6p21.1; chr6:43037617-43053943 (-) GRCh38

MGI Vertebrate Homology

Cul7 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: CUL7
Gene Tree

Cul7

Diseases

1 with human CUL7 associations

				Human Disease	Mouse Models
				3-M syndrome IDs 3-M syndrome DOID:0060241 MESH:C535314 OMIM:273750 OMIM:612921 OMIM:614205 ORDO:2616 UMLS_CUI:C1848862 UMLS_CUI:C3280146

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

3
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

72 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

During late gestation, homozygous null fetuses display reduced growth associated with abnormal placental development and hemorrhaging due to vascular defects. Mutant mice are born but die shortly after birth, succumbing to respiratory distress.

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All GO Annotations

42
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

783
Tissues

19
cDNA Data

117
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

73
RefSeq

2
UniProt

8
CCDS

CCDS28833.1

Ensembl

ENSMUSG00000038545 (Evidence)
NCBI Gene

66515

			Length	Strain/Species	Flank
genomic	66515	NCBI Gene Model \| MGI Sequence Detail	14027	C57BL/6J	± kb
transcript	NM_025611	RefSeq \| MGI Sequence Detail	5546	C57BL/6
polypeptide	Q8VE73	UniProt \| EBI \| MGI Sequence Detail	1689	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000006052 cullin-7

(term hierarchy)
InterPro Domains

IPR004939 APC10/DOC domain

IPR016024 Armadillo-type fold

IPR021097 CPH domain

IPR045093 Cullin

IPR016157 Cullin, conserved site

IPR016158 Cullin homology domain

IPR036317 Cullin homology domain superfamily

IPR001373 Cullin, N-terminal

IPR019559 Cullin protein, neddylation domain

IPR008979 Galactose-binding-like domain superfamily

IPR014722 Large ribosomal subunit protein uL2, domain 2

IPR036388 Winged helix-like DNA-binding domain superfamily
GlyGen

Q8VE73 1 site, 1 O-linked glycan (1 site)

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All nucleic 118

cDNA 117

Primer pair 1

Microarray probesets 3

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MGI:2146763, MGI:2444257

Summaries

All 49

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cul7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144864	Chr17:46961254-46961266 (+)	-4 bp
Tssr144865	Chr17:46961476-46961494 (+)	221 bp
Tssr144866	Chr17:46961501-46961515 (+)	244 bp
Tssr144867	Chr17:46961534-46961560 (+)	283 bp
Tssr144868	Chr17:46961568-46961587 (+)	314 bp
Tssr144869	Chr17:46966441-46966446 (+)	5,180 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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