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Aggf1 Gene Detail
Summary
  • Symbol
    Aggf1
  • Name
    angiogenic factor with G patch and FHA domains 1
  • Synonyms
    2010009L17Rik, 2310029P06Rik, VG5Q
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913799
    NCBI Gene: 66549
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:95487191-95511860 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 49.41 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    695 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913799
 protein coding gene Chr13:95487191-95511865 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020839
 protein coding gene Chr13:96808042-96832711 (-)
A/J MGP_AJ_G0020793
 protein coding gene Chr13:93180801-93205471 (-)
AKR/J MGP_AKRJ_G0020767
 protein coding gene Chr13:96023411-96048080 (-)
BALB/cJ MGP_BALBcJ_G0020790
 protein coding gene Chr13:93862016-93886685 (-)
C3H/HeJ MGP_C3HHeJ_G0020583
 protein coding gene Chr13:95724530-95749200 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021226
 protein coding gene Chr13:99752731-99777400 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018795
 protein coding gene Chr13:89017607-89044991 (-)
CAST/EiJ MGP_CASTEiJ_G0020102
 protein coding gene Chr13:95020807-95045688 (-)
CBA/J MGP_CBAJ_G0020542
 protein coding gene Chr13:103709788-103734456 (-)
DBA/2J MGP_DBA2J_G0020667
 protein coding gene Chr13:92966216-92990884 (-)
FVB/NJ MGP_FVBNJ_G0020648
 protein coding gene Chr13:91751969-91776638 (-)
LP/J MGP_LPJ_G0020742
 protein coding gene Chr13:96930817-96955487 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020676
 protein coding gene Chr13:104155790-104180459 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021266
 protein coding gene Chr13:95428442-95453111 (-)
PWK/PhJ MGP_PWKPhJ_G0019854
 protein coding gene Chr13:91727253-91753716 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019678
 protein coding gene Chr13:91715337-91739892 (-)
WSB/EiJ MGP_WSBEiJ_G0020159
 protein coding gene Chr13:95926763-95951433 (-)



Homology
more
  • Human Ortholog
    AGGF1, angiogenic factor with G-patch and FHA domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AGGF1, angiogenic factor with G-patch and FHA domains 1
  • Synonyms
    GPATC7, GPATCH7, HSU84971, HUS84971, VG5Q
  • Links
    NCBI Gene ID: 55109
    neXtProt AC: NX_Q8N302
    UniProt: Q8N302

  • Chr Location
    5q13.3; chr5:77029251-77065234 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die before E8.5. Heterozygotes exhibit defective angiogenesis in yolk sacs and embryos and partial lethality. Surviving adults show hemorrhages, increased vascular permeability, and reduced tumor growth of implanted melanoma cell lines.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    758
  • Tissues
    51
  • cDNA Data
    113
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021681 Ensembl Gene Model | MGI Sequence Detail 24670 C57BL/6J ±  kb
    transcript ENSMUST00000022189 Ensembl | MGI Sequence Detail 3249 Not Applicable  
    polypeptide ENSMUSP00000022189 Ensembl | MGI Sequence Detail 711 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 114
      cDNA 113
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2145413, MGI:2447861
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 7
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:28008 Harrison SM, et al., Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Development. 1995 Aug;121(8):2479-89
    • Latest
      J:335321 Da X, et al., AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin alpha7-mediated inhibition of TGF-beta1 maturation and ERK1/2 signaling. Nat Commun. 2023 Apr 20;14(1):2265
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory