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Mgst1 Gene Detail
Summary
  • Symbol
    Mgst1
  • Name
    microsomal glutathione S-transferase 1
  • Synonyms
    1500002K10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913850
    NCBI Gene: 56615
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:138117525-138133753 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 68.40 cM, cytoband G1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    643 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913850
 protein coding gene Chr6:138117314-138133753 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031440
 protein coding gene Chr6:142708901-142725550 (+)
A/J MGP_AJ_G0031415
 protein coding gene Chr6:137085620-137102336 (+)
AKR/J MGP_AKRJ_G0031343
 protein coding gene Chr6:141257003-141274377 (+)
BALB/cJ MGP_BALBcJ_G0031422
 protein coding gene Chr6:136942263-136961495 (+)
C3H/HeJ MGP_C3HHeJ_G0031144
 protein coding gene Chr6:141270154-141288543 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031884
 protein coding gene Chr6:146567846-146584891 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029013
 protein coding gene Chr6:136105022-136122685 (+)
CAST/EiJ MGP_CASTEiJ_G0030512
 protein coding gene Chr6:140770068-140792208 (+)
CBA/J MGP_CBAJ_G0031104
 protein coding gene Chr6:152174439-152193718 (+)
DBA/2J MGP_DBA2J_G0031261
 protein coding gene Chr6:135936846-135955896 (+)
FVB/NJ MGP_FVBNJ_G0031212
 protein coding gene Chr6:134805409-134821772 (+)
LP/J MGP_LPJ_G0031345
 protein coding gene Chr6:142847685-142864024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031252
 protein coding gene Chr6:155971319-155993629 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031916
 protein coding gene Chr6:140988755-141005350 (+)
PWK/PhJ MGP_PWKPhJ_G0030239
 protein coding gene Chr6:134423160-134440438 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030063
 protein coding gene Chr6:139240391-139257825 (+)
WSB/EiJ MGP_WSBEiJ_G0030605
 protein coding gene Chr6:141631632-141651977 (+)



Homology
more
  • Human Ortholog
    MGST1, microsomal glutathione S-transferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGST1, microsomal glutathione S-transferase 1
  • Synonyms
    GST12, MGST, MGST-I, PMAN
  • Links
    NCBI Gene ID: 4257
    neXtProt AC: NX_P10620
    UniProt: P10620

  • Chr Location
    12p12.3; chr12:16347115-16609259 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality prior to E7.5-E10.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    24
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1336
  • Tissues
    168
  • cDNA Data
    698
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56615 NCBI Gene Model | MGI Sequence Detail 16229 C57BL/6J ±  kb
    transcript NM_001347489 RefSeq | MGI Sequence Detail 1172 C57BL/6  
    polypeptide Q91VS7 UniProt | EBI | MGI Sequence Detail 155 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000010390 microsomal glutathione S-transferase 1
      (term hierarchy)
    • EC
      2.5.1.18
    • InterPro Domains
      IPR023352 Membrane associated eicosanoid/glutathione metabolism-like domain superfamily
      IPR001129 Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein
      IPR040162 Microsomal glutathione S-transferase 1-like
    • GlyGen
      Q91VS7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 699
      cDNA 698
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:61967 Raza H, et al., Cloning, characterisation and bacterial expression of full length cDNA for the mouse liver microsomal glutathione S-transferase. Oncol Rep. 2000 May-Jun;7(3):645-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory