Tmigd1 MGI Mouse Gene Detail - MGI:1913851 - transmembrane and immunoglobulin domain containing 1

Symbol

Tmigd1
Name

transmembrane and immunoglobulin domain containing 1
Synonyms

2010002A20Rik

Feature Type

protein coding gene
IDs

MGI:1913851
NCBI Gene: 66601
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:76792985-76807413 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 46.15 cM, cytoband B5
Mapping Data

2 experiments

SNPs within 2kb

410 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913851	protein coding gene	Chr11:76781946-76807413 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018740	protein coding gene	Chr11:77754671-77769934 (+)
A/J	MGP_AJ_G0018706	protein coding gene	Chr11:74840238-74854639 (+)
AKR/J	MGP_AKRJ_G0018676	protein coding gene	Chr11:77100173-77117229 (+)
BALB/cJ	MGP_BALBcJ_G0018680	protein coding gene	Chr11:75222036-75236596 (+)
C3H/HeJ	MGP_C3HHeJ_G0018493	protein coding gene	Chr11:77127804-77142683 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019131	protein coding gene	Chr11:80202740-80218325 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016766	protein coding gene	Chr11:71832925-71847170 (+)
CAST/EiJ	MGP_CASTEiJ_G0018047	protein coding gene	Chr11:77522474-77538802 (+)
CBA/J	MGP_CBAJ_G0018463	protein coding gene	Chr11:83695051-83715185 (+)
DBA/2J	MGP_DBA2J_G0018572	protein coding gene	Chr11:74428666-74443457 (+)
FVB/NJ	MGP_FVBNJ_G0018562	protein coding gene	Chr11:73987143-74001926 (+)
LP/J	MGP_LPJ_G0018643	protein coding gene	Chr11:78368355-78382900 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018588	protein coding gene	Chr11:84157253-84175488 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019171	protein coding gene	Chr11:77310976-77328136 (+)
PWK/PhJ	MGP_PWKPhJ_G0017818	protein coding gene	Chr11:75169234-75184736 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017609	protein coding gene	Chr11:76893550-76908295 (+)
WSB/EiJ	MGP_WSBEiJ_G0018100	protein coding gene	Chr11:77135230-77154793 (+)

Human Ortholog

TMIGD1, transmembrane and immunoglobulin domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMIGD1, transmembrane and immunoglobulin domain containing 1
Synonyms

TMIGD, UNQ9372
Links

HGNC:32431

NCBI Gene ID: 388364

neXtProt AC: NX_Q6UXZ0

UniProt: Q6UXZ0
Chr Location

17q11.2; chr17:30316333-30334059 (-) GRCh38

MGI Vertebrate Homology

Tmigd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TMIGD1
Gene Tree

Tmigd1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Targeted

4
Genomic Mutations

2 involving Tmigd1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele develop intestinal hyperplasia, and polyps in small intestine, large intestine, and rectum.

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All GO Annotations

34
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmigd1

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All Sequences

45
RefSeq

10
UniProt

3
CCDS

CCDS25072.1

Ensembl

ENSMUSG00000020839 (Evidence)
NCBI Gene

66601

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020839	Ensembl Gene Model \| MGI Sequence Detail	14429	C57BL/6J	± kb
transcript	ENSMUST00000102495	Ensembl \| MGI Sequence Detail	1427	Not Applicable
polypeptide	ENSMUSP00000099553	Ensembl \| MGI Sequence Detail	261	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000032063 transmembrane and immunoglobulin domain-containing protein 1

(term hierarchy)
InterPro Domains

IPR013098 Immunoglobulin I-set

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR003599 Immunoglobulin subtype

IPR003598 Immunoglobulin subtype 2

IPR051170 Neural and epithelial cell adhesion domain-containing protein
GlyGen

Q9D7L8 6 sites

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All nucleic 16

cDNA 16

Microarray probesets 2

Summaries

All 39

Gene Ontology 6

Phenotypes 17
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:341228 Belghasem M, et al., Tryptophan Metabolites Target Transmembrane and Immunoglobulin Domain-Containing 1 Signaling to Augment Renal Tubular Injury. Am J Pathol. 2023 Oct;193(10):1501-1516

TSS for Tmigd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3580	Chr11:76792846-76792863 (+)	-130 bp
Tssr103111	Chr11:76792978-76792993 (+)	1 bp
Tssr103112	Chr11:76793000-76793006 (+)	18 bp
Tssr103113	Chr11:76793008-76793011 (+)	25 bp
Tssr3581	Chr11:76795292-76795295 (+)	2,309 bp
Tssr103114	Chr11:76795310-76795329 (+)	2,335 bp
Tssr103115	Chr11:76795339-76795395 (+)	2,382 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24