Gemin2 MGI Mouse Gene Detail - MGI:1913853 - gem nuclear organelle associated protein 2

Symbol

Gemin2
Name

gem nuclear organelle associated protein 2
Synonyms

1700012N19Rik, Sip1

Feature Type

protein coding gene
IDs

MGI:1913853
NCBI Gene: 66603
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:59060179-59075256 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 25.99 cM, cytoband C2
Mapping Data

2 experiments

SNPs within 2kb

586 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913853	protein coding gene	Chr12:59060177-59075256 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019766	protein coding gene	Chr12:58207223-58222276 (+)
A/J	MGP_AJ_G0019725	protein coding gene	Chr12:56094595-56109626 (+)
AKR/J	MGP_AKRJ_G0019700	protein coding gene	Chr12:57876620-57891723 (+)
BALB/cJ	MGP_BALBcJ_G0019705	protein coding gene	Chr12:56475853-56491091 (+)
C3H/HeJ	MGP_C3HHeJ_G0019510	protein coding gene	Chr12:57975125-57991226 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020157	protein coding gene	Chr12:59912857-59929543 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017777	protein coding gene	Chr12:54467456-54483961 (+)
CAST/EiJ	MGP_CASTEiJ_G0019062	protein coding gene	Chr12:52863838-52883440 (+)
CBA/J	MGP_CBAJ_G0019479	protein coding gene	Chr12:62123133-62143340 (+)
DBA/2J	MGP_DBA2J_G0019595	protein coding gene	Chr12:56009306-56024362 (+)
FVB/NJ	MGP_FVBNJ_G0019583	protein coding gene	Chr12:55279403-55294084 (+)
LP/J	MGP_LPJ_G0019667	protein coding gene	Chr12:58248014-58263754 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019621	protein coding gene	Chr12:63729473-63746315 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020191	protein coding gene	Chr12:57320329-57338553 (+)
PWK/PhJ	MGP_PWKPhJ_G0018829	protein coding gene	Chr12:50374898-50390942 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018622	protein coding gene	Chr12:51721209-51736647 (+)
WSB/EiJ	MGP_WSBEiJ_G0019113	protein coding gene	Chr12:57886911-57901915 (+)

Human Ortholog

GEMIN2, gem nuclear organelle associated protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GEMIN2, gem nuclear organelle associated protein 2
Synonyms

SIP1, SIP1-delta
Links

HGNC:10884

NCBI Gene ID: 8487

neXtProt AC: NX_O14893

UniProt: O14893
Chr Location

14q21.1; chr14:39114285-39136973 (+) GRCh38

MGI Vertebrate Homology

Gemin2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GEMIN2
Protein SuperFamily

SMN_Gemin2
Gene Tree

Gemin2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

24
Targeted

2
Genomic Mutations

1 involving Gemin2
Incidental Mutations

APF
Find Mice (IMSR)

10 strains or lines available

Mice homozygous for disruptions in this gene die as embryos.

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All GO Annotations

23
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

828
Tissues

79
cDNA Data

21
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GEMIN2

Xenbase gemin2

ZFIN gemin2

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS36457.1

Ensembl

ENSMUSG00000060121 (Evidence)
NCBI Gene

66603

			Length	Strain/Species	Flank
genomic	ENSMUSG00000060121	Ensembl Gene Model \| MGI Sequence Detail	15078	C57BL/6J	± kb
transcript	ENSMUST00000021379	Ensembl \| MGI Sequence Detail	1588	Not Applicable
polypeptide	ENSMUSP00000021379	Ensembl \| MGI Sequence Detail	269	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014879 gem-associated protein 2

(term hierarchy)
InterPro Domains

IPR017364 Gem-associated protein 2

IPR035426 Gemin2/Brr1

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All nucleic 25

cDNA 22

Primer pair 3

Microarray probesets 4

Summaries

All 46

Developmental Gene Expression 12

Gene Ontology 7

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:319558 Bizen N, et al., Ddx20, an Olig2 binding factor, governs the survival of neural and oligodendrocyte progenitor cells via proper Mdm2 splicing and p53 suppression. Cell Death Differ. 2022;

TSS for Gemin2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113541	Chr12:59060165-59060184 (+)	-4 bp
Tssr113542	Chr12:59060197-59060248 (+)	44 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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