Ms4a4d MGI Mouse Gene Detail - MGI:1913857 - membrane-spanning 4-domains, subfamily A, member 4D

Symbol

Ms4a4d
Name

membrane-spanning 4-domains, subfamily A, member 4D

Feature Type

protein coding gene
IDs

MGI:1913857
NCBI Gene: 66607
Member of

Ms4ac cluster
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:11514165-11535831 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 8.44 cM, cytoband B
Mapping Data

2 experiments

SNPs within 2kb

860 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913857	protein coding gene	Chr19:11514158-11535831 (+)
129S1/SvImJ	no annotation
A/J	MGP_AJ_G0024851	protein coding gene	Chr19:8414462-8440700 (+)
AKR/J	MGP_AKRJ_G0024826	protein coding gene	Chr19:8722814-8758861 (+)
BALB/cJ	MGP_BALBcJ_G0024851	protein coding gene	Chr19:8414568-8444225 (+)
C3H/HeJ	MGP_C3HHeJ_G0024617	protein coding gene	Chr19:8631408-8655594 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025299	protein coding gene	Chr19:9387848-9400950 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022731	protein coding gene	Chr19:8987496-9013263 (+)
CAST/EiJ	MGP_CASTEiJ_G0024090	protein coding gene	Chr19:8248579-8258100 (-)
CBA/J	MGP_CBAJ_G0024591	protein coding gene	Chr19:9425818-9461675 (+)
DBA/2J	MGP_DBA2J_G0024718	protein coding gene	Chr19:8364766-8406326 (+)
FVB/NJ	MGP_FVBNJ_G0024685	protein coding gene	Chr19:8420861-8446298 (+)
LP/J	MGP_LPJ_G0024805	protein coding gene	Chr19:8921829-8951305 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024712	protein coding gene	Chr19:9321849-9356567 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025347	protein coding gene	Chr19:8700951-8743102 (+)
PWK/PhJ	MGP_PWKPhJ_G0023834	protein coding gene	Chr19:7833486-7857881 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023640	protein coding gene	Chr19:7887241-7908699 (+)
WSB/EiJ	MGP_WSBEiJ_G0024152	protein coding gene	Chr19:8574589-8600398 (+)

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MGI Vertebrate Homology

Ms4a4d stringent orthology
1 mouse;1 rat;8 zebrafish
Gene Tree

Ms4a4d

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

2

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

15

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

29
RefSeq

2
UniProt

1
CCDS

CCDS29602.1

Ensembl

ENSMUSG00000024678 (Evidence)
NCBI Gene

66607

			Length	Strain/Species	Flank
genomic	ENSMUSG00000024678	Ensembl Gene Model \| MGI Sequence Detail	21667	C57BL/6J	± kb
transcript	ENSMUST00000025581	Ensembl \| MGI Sequence Detail	1513	Not Applicable
polypeptide	ENSMUSP00000025581	Ensembl \| MGI Sequence Detail	225	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010919 membrane-spanning 4-domains subfamily A member 4D

(term hierarchy)
InterPro Domains

IPR007237 CD20-like family

IPR030417 Membrane-spanning 4-domains subfamily A

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All nucleic 15

cDNA 15

Microarray probesets 3

Summaries

All 30

Gene Ontology 2

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ms4a4d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr155260	Chr19:11514133-11514210 (+)	7 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24