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Ormdl3 Gene Detail
Summary
  • Symbol
    Ormdl3
  • Name
    ORM1-like 3 (S. cerevisiae)
  • Synonyms
    2810011N17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913862
    NCBI Gene: 66612
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98472120-98478071 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 62.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913862
 protein coding gene Chr11:98472082-98478194 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019064
 protein coding gene Chr11:101142264-101150572 (-)
A/J MGP_AJ_G0019032
 protein coding gene Chr11:96929232-96935325 (-)
AKR/J MGP_AKRJ_G0019002
 protein coding gene Chr11:99934309-99940397 (-)
BALB/cJ MGP_BALBcJ_G0019005
 protein coding gene Chr11:97423200-97430041 (-)
C3H/HeJ MGP_C3HHeJ_G0018819
 protein coding gene Chr11:100069759-100077267 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019458
 protein coding gene Chr11:104229175-104238606 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017089
 protein coding gene Chr11:94369656-94375693 (-)
CAST/EiJ MGP_CASTEiJ_G0018373
 protein coding gene Chr11:100950693-100963482 (-)
CBA/J MGP_CBAJ_G0018790
 protein coding gene Chr11:108549069-108558696 (-)
DBA/2J MGP_DBA2J_G0018898
 protein coding gene Chr11:96472898-96478960 (-)
FVB/NJ MGP_FVBNJ_G0018887
 protein coding gene Chr11:95983986-95993230 (-)
LP/J MGP_LPJ_G0018968
 protein coding gene Chr11:101617233-101623283 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018914
 protein coding gene Chr11:108325113-108332159 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019498
 protein coding gene Chr11:100264220-100270315 (-)
PWK/PhJ MGP_PWKPhJ_G0018145
 protein coding gene Chr11:97480419-97490863 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017935
 protein coding gene Chr11:99966911-99974950 (-)
WSB/EiJ MGP_WSBEiJ_G0018423
 protein coding gene Chr11:100191513-100197584 (-)



Homology
more
  • Human Ortholog
    ORMDL3, ORMDL sphingolipid biosynthesis regulator 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ORMDL3, ORMDL sphingolipid biosynthesis regulator 3
  • Links
    NCBI Gene ID: 94103
    neXtProt AC: NX_Q8N138
    UniProt: Q8N138

  • Chr Location
    17q21.1; chr17:39921041-39927601 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a small spleen with a lower ratio of white pulp to red pulp and disproportional B cell subsets.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    3
  • cDNA Data
    105
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66612 NCBI Gene Model | MGI Sequence Detail 5952 C57BL/6J ±  kb
    transcript NM_025661 RefSeq | MGI Sequence Detail 2023 C57BL/6  
    polypeptide Q9CPZ6 UniProt | EBI | MGI Sequence Detail 153 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      cDNA 105
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144109
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:349249 Demkova L, et al., Simultaneous deletion of ORMDL1 and ORMDL3 proteins disrupts immune cell homeostasis. Front Immunol. 2024;15:1376629
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory