Gpatch4 MGI Mouse Gene Detail - MGI:1913864 - G patch domain containing 4

Symbol

Gpatch4
Name

G patch domain containing 4
Synonyms

2610029K21Rik, Gpatc4

Feature Type

protein coding gene
IDs

MGI:1913864
NCBI Gene: 66614
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr3:87950415-87963300 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 38.78 cM, cytoband F1
Mapping Data

2 experiments

SNPs within 2kb

374 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913864	protein coding gene	Chr3:87950413-87963301 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027380	protein coding gene	Chr3:88179253-88194249 (+)
A/J	MGP_AJ_G0027344	protein coding gene	Chr3:85187554-85200711 (+)
AKR/J	MGP_AKRJ_G0027310	protein coding gene	Chr3:87281576-87295269 (+)
BALB/cJ	MGP_BALBcJ_G0027353	protein coding gene	Chr3:85281119-85293772 (+)
C3H/HeJ	MGP_C3HHeJ_G0027096	protein coding gene	Chr3:87563138-87576617 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027799	protein coding gene	Chr3:91426037-91441967 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025152	protein coding gene	Chr3:80819567-80831303 (+)
CAST/EiJ	MGP_CASTEiJ_G0026542	protein coding gene	Chr3:87768462-87781770 (+)
CBA/J	MGP_CBAJ_G0027071	protein coding gene	Chr3:94522241-94538354 (+)
DBA/2J	MGP_DBA2J_G0027207	protein coding gene	Chr3:84677774-84690350 (+)
FVB/NJ	MGP_FVBNJ_G0027176	protein coding gene	Chr3:82952217-82965212 (+)
LP/J	MGP_LPJ_G0027315	protein coding gene	Chr3:89148979-89162929 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027195	protein coding gene	Chr3:100778353-100793756 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027857	protein coding gene	Chr3:87037323-87052286 (+)
PWK/PhJ	MGP_PWKPhJ_G0026275	protein coding gene	Chr3:84473724-84486814 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026093	protein coding gene	Chr3:86222119-86234512 (+)
WSB/EiJ	MGP_WSBEiJ_G0026622	protein coding gene	Chr3:87396596-87410285 (+)

Human Ortholog

GPATCH4, G-patch domain containing 4 (gene/pseudogene)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPATCH4, G-patch domain containing 4 (gene/pseudogene)
Synonyms

GPATC4
Links

HGNC:25982

NCBI Gene ID: 54865

UniProt: Q5T3I0
Chr Location

1q22-q23.1; chr1:156594301-156601496 (-) GRCh38

MGI Vertebrate Homology

Gpatch4 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GPATCH4
Gene Tree

Gpatch4

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References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

35
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Gpatch4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

5
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

22
cDNA Data

34
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpatch4

ZFIN gpatch4

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All Sequences

49
RefSeq

6
UniProt

2
CCDS

CCDS50948.1

Ensembl

ENSMUSG00000028069 (Evidence)
NCBI Gene

66614

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028069	Ensembl Gene Model \| MGI Sequence Detail	12886	C57BL/6J	± kb
transcript	ENSMUST00000193398	Ensembl \| MGI Sequence Detail	2210	Not Applicable
polypeptide	ENSMUSP00000141786	Ensembl \| MGI Sequence Detail	415	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029519 G patch domain-containing protein 4

(term hierarchy)
InterPro Domains

IPR000467 G-patch domain

IPR050656 PIN2/TERF1-interacting telomerase inhibitor

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All nucleic 36

cDNA 35

Primer pair 1

Microarray probesets 5

Summaries

All 41

Developmental Gene Expression 1

Diseases 1

Gene Ontology 4

Phenotypes 14
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426

TSS for Gpatch4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29890	Chr3:87950405-87950435 (+)	5 bp
Tssr29891	Chr3:87950438-87950457 (+)	33 bp
Tssr29892	Chr3:87962430-87962441 (+)	12,021 bp
Tssr29893	Chr3:87962791-87962799 (+)	12,380 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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