Thg1l MGI Mouse Gene Detail - MGI:1913878 - tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)

Symbol

Thg1l
Name

tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
Synonyms

1700121M19Rik, 5730409G07Rik

Feature Type

protein coding gene
IDs

MGI:1913878
NCBI Gene: 66628
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:45837670-45846321 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 27.47 cM, cytoband B1.2
Mapping Data

3 experiments

SNPs within 2kb

361 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913878	protein coding gene	Chr11:45836132-45846330 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018186	protein coding gene	Chr11:44831260-44839927 (-)
A/J	MGP_AJ_G0018158	protein coding gene	Chr11:43113890-43122546 (-)
AKR/J	MGP_AKRJ_G0018122	protein coding gene	Chr11:44355028-44363668 (-)
BALB/cJ	MGP_BALBcJ_G0018127	protein coding gene	Chr11:43279096-43287769 (-)
C3H/HeJ	MGP_C3HHeJ_G0017941	protein coding gene	Chr11:44401981-44410648 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018581	protein coding gene	Chr11:46173926-46182577 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016236	protein coding gene	Chr11:41110536-41119394 (-)
CAST/EiJ	MGP_CASTEiJ_G0017504	protein coding gene	Chr11:44506136-44514815 (-)
CBA/J	MGP_CBAJ_G0017913	protein coding gene	Chr11:48327735-48336408 (-)
DBA/2J	MGP_DBA2J_G0018023	protein coding gene	Chr11:42866740-42875399 (-)
FVB/NJ	MGP_FVBNJ_G0018017	protein coding gene	Chr11:42545851-42554502 (-)
LP/J	MGP_LPJ_G0018095	protein coding gene	Chr11:45080908-45089573 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018041	protein coding gene	Chr11:49876562-49885227 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018620	protein coding gene	Chr11:44523579-44532241 (-)
PWK/PhJ	MGP_PWKPhJ_G0017284	protein coding gene	Chr11:42942767-42951603 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017077	protein coding gene	Chr11:44305717-44316481 (-)
WSB/EiJ	MGP_WSBEiJ_G0017554	protein coding gene	Chr11:44216521-44225172 (-)

Human Ortholog

THG1L, tRNA-histidine guanylyltransferase 1 like

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

THG1L, tRNA-histidine guanylyltransferase 1 like
Synonyms

hTHG1, ICF45, IHG-1, IHG1, SCAR28, THG1
Links

HGNC:26053

NCBI Gene ID: 54974

neXtProt AC: NX_Q9NWX6

UniProt: Q9NWX6
Chr Location

5q33.3; chr5:157731420-157741449 (+) GRCh38

MGI Vertebrate Homology

Thg1l stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: THG1L
Protein SuperFamily

tRNAHis_guanylyltransferase
Gene Tree

Thg1l

Diseases

1 with human THG1L associations

				Human Disease	Mouse Models
				autosomal recessive spinocerebellar ataxia 28 IDs autosomal recessive spinocerebellar ataxia 28 DOID:0070409 OMIM:618800

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Thg1l
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

32
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

13

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase thg1l

ZFIN thg1l

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All Sequences

51
RefSeq

8
UniProt

4
CCDS

CCDS36132.1, CCDS70167.1

Ensembl

ENSMUSG00000011254 (Evidence)
NCBI Gene

66628

			Length	Strain/Species	Flank
genomic	ENSMUSG00000011254	Ensembl Gene Model \| MGI Sequence Detail	8652	C57BL/6J	± kb
transcript	ENSMUST00000011398	Ensembl \| MGI Sequence Detail	2250	Not Applicable
polypeptide	ENSMUSP00000011398	Ensembl \| MGI Sequence Detail	298	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029790 probable tRNA(His) guanylyltransferase

(term hierarchy)
EC

2.7.7.79
InterPro Domains

IPR025845 Thg1 C-terminal domain

IPR024956 tRNAHis guanylyltransferase catalytic domain

IPR007537 tRNAHis guanylyltransferase Thg1

IPR038469 tRNAHis guanylyltransferase Thg1 superfamily

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All nucleic 13

cDNA 13

Microarray probesets 3

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MGI:1920871, MGI:3034616

Summaries

All 40

Gene Ontology 6

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Thg1l:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107581	Chr11:45846292-45846318 (-)	16 bp
Tssr107580	Chr11:45846253-45846264 (-)	62 bp
Tssr107579	Chr11:45846010-45846020 (-)	306 bp
Tssr107578	Chr11:45845991-45846009 (-)	321 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24