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Sike1 Gene Detail
Summary
  • Symbol
    Sike1
  • Name
    suppressor of IKBKE 1
  • Synonyms
    2810005O12Rik, 5730470L24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913891
    NCBI Gene: 66641
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:102903056-102911230 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.25 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913891
 protein coding gene Chr3:102903024-102915775 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027687
 protein coding gene Chr3:104237167-104249832 (+)
A/J MGP_AJ_G0027646
 protein coding gene Chr3:100922602-100937317 (+)
AKR/J MGP_AKRJ_G0027612
 protein coding gene Chr3:103407787-103420539 (+)
BALB/cJ MGP_BALBcJ_G0027659
 protein coding gene Chr3:100695384-100708133 (+)
C3H/HeJ MGP_C3HHeJ_G0027388
 protein coding gene Chr3:103725682-103738374 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028102
 protein coding gene Chr3:108102958-108115709 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025443
 protein coding gene Chr3:97067072-97080449 (+)
CAST/EiJ MGP_CASTEiJ_G0026845
 protein coding gene Chr3:102840868-102853526 (+)
CBA/J MGP_CBAJ_G0027363
 protein coding gene Chr3:111791562-111804235 (+)
DBA/2J MGP_DBA2J_G0027506
 protein coding gene Chr3:100175638-100188295 (+)
FVB/NJ MGP_FVBNJ_G0027474
 protein coding gene Chr3:98106663-98119414 (+)
LP/J MGP_LPJ_G0027613
 protein coding gene Chr3:105568855-105581533 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027503
 protein coding gene Chr3:117957344-117971744 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028157
 protein coding gene Chr3:102913176-102926581 (+)
PWK/PhJ MGP_PWKPhJ_G0026571
 protein coding gene Chr3:99915566-99928606 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026393
 protein coding gene Chr3:101010074-101022852 (+)
WSB/EiJ MGP_WSBEiJ_G0026924
 protein coding gene Chr3:103482040-103495741 (+)



Homology
more
  • Human Ortholog
    SIKE1, suppressor of IKBKE 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIKE1, suppressor of IKBKE 1
  • Synonyms
    SIKE
  • Links
    NCBI Gene ID: 80143
    neXtProt AC: NX_Q9BRV8
    UniProt: Q9BRV8

  • Chr Location
    1p13.2; chr1:114769479-114780685 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Sike1
  • Incidental Mutations
    Mutagenetix
  • Find Mice (IMSR)
    15 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    9
  • cDNA Data
    14
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66641 NCBI Gene Model | MGI Sequence Detail 8175 C57BL/6J ±  kb
transcript NM_025679 RefSeq | MGI Sequence Detail 2798 C57BL/6  
polypeptide Q9CPR7 UniProt | EBI | MGI Sequence Detail 207 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 9
Other
Accession IDs
less
MGI:1919901, MGI:2139715, MGI:2139805
References
more
  • Summaries
    All 39
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345845 Bai L, et al., Multispecies transcriptomics identifies SIKE as a MAPK repressor that prevents NASH progression. Sci Transl Med. 2024 Feb 14;16(734):eade7347
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory