Ctnnbl1 MGI Mouse Gene Detail - MGI:1913892

Symbol

Ctnnbl1
Name

catenin, beta like 1
Synonyms

5730471K09Rik, FLJ21108, NYD-SP19, P14L

Feature Type

protein coding gene
IDs

MGI:1913892
NCBI Gene: 66642
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr2:157579321-157733534 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.40 cM, cytoband H2
Mapping Data

3 experiments

SNPs within 2kb

3129 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913892	protein coding gene	Chr2:157579321-157733823 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026785	protein coding gene	Chr2:162761181-162923377 (+)
A/J	MGP_AJ_G0026751	protein coding gene	Chr2:156243938-156402608 (+)
AKR/J	MGP_AKRJ_G0026722	protein coding gene	Chr2:160864723-161022953 (+)
BALB/cJ	MGP_BALBcJ_G0026760	protein coding gene	Chr2:156554322-156707495 (+)
C3H/HeJ	MGP_C3HHeJ_G0026502	protein coding gene	Chr2:161164314-161324348 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027209	protein coding gene	Chr2:167609156-167769216 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024579	protein coding gene	Chr2:149689902-149849321 (+)
CAST/EiJ	MGP_CASTEiJ_G0025964	protein coding gene	Chr2:161523817-161684285 (+)
CBA/J	MGP_CBAJ_G0026479	protein coding gene	Chr2:173635221-173796547 (+)
DBA/2J	MGP_DBA2J_G0026617	protein coding gene	Chr2:155427154-155581230 (+)
FVB/NJ	MGP_FVBNJ_G0026584	protein coding gene	Chr2:153826034-153980974 (+)
LP/J	MGP_LPJ_G0026720	protein coding gene	Chr2:162850896-163011917 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026605	protein coding gene	Chr2:177472648-177629818 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027265	protein coding gene	Chr2:160670851-160830266 (+)
PWK/PhJ	MGP_PWKPhJ_G0025698	protein coding gene	Chr2:154941797-155097875 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025501	protein coding gene	Chr2:159600974-159760957 (+)
WSB/EiJ	MGP_WSBEiJ_G0026034	protein coding gene	Chr2:161567246-161729938 (+)

Human Ortholog

CTNNBL1, catenin beta like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTNNBL1, catenin beta like 1
Synonyms

C20orf33, dJ633O20.1, IMD99, NAP, P14L, PP8304
Links

HGNC:15879

NCBI Gene ID: 56259

neXtProt AC: NX_Q8WYA6

UniProt: Q8WYA6
Chr Location

20q11.23; chr20:37694030-37872129 (+) GRCh38

MGI Vertebrate Homology

Ctnnbl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CTNNBL1
Gene Tree

Ctnnbl1

Diseases

3 with human CTNNBL1 associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 ICD10CM:C18.9 KEGG:05210 MESH:D015179 NCI:C2956 NCI:C4978 OMIM:114500 UMLS_CUI:C0009404 UMLS_CUI:C0346629
				morbid obesity IDs morbid obesity DOID:11981 ICD9CM:278.01 MESH:D009767 NCI:C34858 UMLS_CUI:C0028756
				primary immunodeficiency disease IDs primary immunodeficiency disease DOID:612 ICD10CM:D84.9 ICD9CM:279.3 KEGG:05340 MESH:D007153 NCI:C39725 OMIM:242850 OMIM:PS300755 UMLS_CUI:C0021051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 4 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

74
Endonuclease-mediated

1
Gene trapped

70
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

715
Tissues

9
cDNA Data

73
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctnnbl1

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All Sequences

49
RefSeq

4
UniProt

3
CCDS

CCDS16982.1

Ensembl

ENSMUSG00000027649 (Evidence)
NCBI Gene

66642

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027649	Ensembl Gene Model \| MGI Sequence Detail	154214	C57BL/6J	± kb
transcript	ENSMUST00000029178	Ensembl \| MGI Sequence Detail	2442	Not Applicable
polypeptide	ENSMUSP00000029178	Ensembl \| MGI Sequence Detail	563	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006011 beta-catenin-like protein 1

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR039678 Beta-catenin-like protein 1

IPR013180 Beta-catenin-like protein 1, N-terminal
GlyGen

Q9CWL8 1 site, 1 N-linked glycan (1 site)

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All nucleic 73

cDNA 73

Microarray probesets 5

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 8
Earliest

J:45934 Korinek V, et al., Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse. Mol Cell Biol. 1998 Mar;18(3):1248-56
Latest

J:320339 Chanarat S, et al., Splicing and beyond: the many faces of the Prp19 complex. Biochim Biophys Acta. 2013 Oct;1833(10):2126-34

TSS for Ctnnbl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21286	Chr2:157579345-157579410 (+)	57 bp
Tssr21287	Chr2:157630471-157630477 (+)	51,153 bp
Tssr21288	Chr2:157635426-157635443 (+)	56,114 bp
Tssr21289	Chr2:157635465-157635475 (+)	56,149 bp
Tssr21290	Chr2:157639269-157639272 (+)	59,950 bp
Tssr21291	Chr2:157659878-157659903 (+)	80,570 bp
Tssr21292	Chr2:157674223-157674235 (+)	94,908 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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