Nepn MGI Mouse Gene Detail - MGI:1913900

Symbol

Nepn
Name

nephrocan
Synonyms

5730521E12Rik, Npn, periolin

Feature Type

protein coding gene
IDs

MGI:1913900
NCBI Gene: 66650
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr10:52265068-52280721 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 26.60 cM, cytoband B3
Mapping Data

2 experiments

SNPs within 2kb

435 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913900	protein coding gene	Chr10:52264961-52280721 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017225	protein coding gene	Chr10:51546083-51563540 (+)
A/J	MGP_AJ_G0017201	protein coding gene	Chr10:50032045-50047654 (+)
AKR/J	MGP_AKRJ_G0017160	protein coding gene	Chr10:50984043-51010705 (+)
BALB/cJ	MGP_BALBcJ_G0017162	protein coding gene	Chr10:50132475-50148786 (+)
C3H/HeJ	MGP_C3HHeJ_G0016984	protein coding gene	Chr10:51239850-51255397 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017621	protein coding gene	Chr10:53181293-53196812 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015315	protein coding gene	Chr10:47252693-47268086 (+)
CAST/EiJ	MGP_CASTEiJ_G0016558	protein coding gene	Chr10:51362658-51379059 (+)
CBA/J	MGP_CBAJ_G0016957	protein coding gene	Chr10:55452379-55468314 (+)
DBA/2J	MGP_DBA2J_G0017062	protein coding gene	Chr10:49443148-49458588 (+)
FVB/NJ	MGP_FVBNJ_G0017056	protein coding gene	Chr10:48792919-48809154 (+)
LP/J	MGP_LPJ_G0017137	protein coding gene	Chr10:51625000-51640562 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017085	protein coding gene	Chr10:57372609-57388929 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017656	protein coding gene	Chr10:50923641-50941406 (+)
PWK/PhJ	MGP_PWKPhJ_G0016339	protein coding gene	Chr10:49304804-49322818 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016124	protein coding gene	Chr10:50536617-50556082 (+)
WSB/EiJ	MGP_WSBEiJ_G0016623	protein coding gene	Chr10:51149966-51165432 (+)

Human Ortholog

NEPNP, nephrocan, pseudogene

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NEPNP, nephrocan, pseudogene
Synonyms

NEPN, NPN
Links

HGNC:33184

NCBI Gene ID: 442253
Chr Location

6q22.1; chr6:117602928-117645087 (+) GRCh38

MGI Vertebrate Homology

Nepn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: NEPNP
Gene Tree

Nepn

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Nepn
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

875
Tissues

71
cDNA Data

19
Literature Summary

19

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

40
RefSeq

6
UniProt

3
CCDS

CCDS23840.1

Ensembl

ENSMUSG00000038624 (Evidence)
NCBI Gene

66650

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038624	Ensembl Gene Model \| MGI Sequence Detail	15654	C57BL/6J	± kb
transcript	ENSMUST00000067085	Ensembl \| MGI Sequence Detail	1844	Not Applicable
polypeptide	ENSMUSP00000070130	Ensembl \| MGI Sequence Detail	512	Not Applicable

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UniProt

3 Sequences
InterPro Domains

IPR001611 Leucine-rich repeat

IPR025875 Leucine rich repeat 4

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR050333 Small Leucine-Rich Proteoglycans
GlyGen

Q9CQ76 1 site

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All nucleic 35

cDNA 20

Primer pair 12

Other 3

Microarray probesets 3

Summaries

All 50

Developmental Gene Expression 19

Gene Ontology 2

Phenotypes 16
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Nepn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr93300	Chr10:52265059-52265073 (+)	-2 bp
Tssr93301	Chr10:52267702-52267706 (+)	2,636 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24