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Spesp1 Gene Detail
Summary
  • Symbol
    Spesp1
  • Name
    sperm equatorial segment protein 1
  • Synonyms
    4921508E09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913962
    NCBI Gene: 66712
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:62178011-62189461 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 33.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    334 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913962
 protein coding gene Chr9:62178011-62189490 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034919
 protein coding gene Chr9:61799136-61810673 (-)
A/J MGP_AJ_G0034899
 protein coding gene Chr9:59771809-59783233 (-)
AKR/J MGP_AKRJ_G0034829
 protein coding gene Chr9:61147946-61159396 (-)
BALB/cJ MGP_BALBcJ_G0034892
 protein coding gene Chr9:59487704-59499138 (-)
C3H/HeJ MGP_C3HHeJ_G0034602
 protein coding gene Chr9:61649687-61661113 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035411
 protein coding gene Chr9:63474086-63485719 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032322
 protein coding gene Chr9:59442618-59454174 (-)
CAST/EiJ MGP_CASTEiJ_G0033923
 protein coding gene Chr9:61784876-61796747 (-)
CBA/J MGP_CBAJ_G0034573
 protein coding gene Chr9:65653075-65666604 (-)
DBA/2J MGP_DBA2J_G0034732
 protein coding gene Chr9:59570463-59581896 (-)
FVB/NJ MGP_FVBNJ_G0034674
 protein coding gene Chr9:58854774-58866223 (-)
LP/J MGP_LPJ_G0034815
 protein coding gene Chr9:62082232-62093583 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034717
 protein coding gene Chr9:67065018-67077573 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035433
 protein coding gene Chr9:61221358-61232737 (-)
PWK/PhJ MGP_PWKPhJ_G0033627
 protein coding gene Chr9:59688171-59699715 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033460
 protein coding gene Chr9:61514881-61528282 (-)
WSB/EiJ MGP_WSBEiJ_G0034036
 protein coding gene Chr9:61138863-61150317 (-)



Homology
more
  • Human Ortholog
    SPESP1, sperm equatorial segment protein 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SPESP1, sperm equatorial segment protein 1
  • Synonyms
    ESP, SP-ESP
  • Links
    NCBI Gene ID: 246777
    neXtProt AC: NX_Q6UW49
    UniProt: Q6UW49

  • Chr Location
    15q23; chr15:68818221-68946811 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous and homozygous null mutant males show decreased fertilization frequency and delayed fertilization, otherwise homozygous null mice were healthy and showed no overt developmental abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66712 NCBI Gene Model | MGI Sequence Detail 11451 C57BL/6J ±  kb
transcript NM_025721 RefSeq | MGI Sequence Detail 3013 C57BL/6  
polypeptide Q9D5A0 UniProt | EBI | MGI Sequence Detail 399 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGI:2143041
References
more
  • Summaries
    All 24
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:285739 Ito C, et al., Deletion of Eqtn in mice reduces male fertility and sperm-egg adhesion. Reproduction. 2018 Dec;156(6):579-590
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory