About   Help   FAQ
Actr2 Gene Detail
Summary
  • Symbol
    Actr2
  • Name
    actin related protein 2
  • Synonyms
    4921510D23Rik, Arp2, D6Ertd746e, MGC:36604
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913963
    NCBI Gene: 66713
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:20012304-20062913 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 12.88 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1569 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913963
 protein coding gene Chr11:20012304-20062951 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018063
 protein coding gene Chr11:17544329-17602112 (-)
A/J MGP_AJ_G0018036
 protein coding gene Chr11:16964328-17020277 (-)
AKR/J MGP_AKRJ_G0018000
 protein coding gene Chr11:17577746-17636167 (-)
BALB/cJ MGP_BALBcJ_G0018004
 protein coding gene Chr11:17088726-17143646 (-)
C3H/HeJ MGP_C3HHeJ_G0017818
 protein coding gene Chr11:17466786-17518689 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018456
 protein coding gene Chr11:18349174-18407751 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016114
 protein coding gene Chr11:15980900-16030565 (-)
CAST/EiJ MGP_CASTEiJ_G0017379
 protein coding gene Chr11:17434769-17486393 (-)
CBA/J MGP_CBAJ_G0017792
 protein coding gene Chr11:19159679-19218660 (-)
DBA/2J MGP_DBA2J_G0017902
 protein coding gene Chr11:16927406-16978591 (-)
FVB/NJ MGP_FVBNJ_G0017894
 protein coding gene Chr11:16657589-16717268 (-)
LP/J MGP_LPJ_G0017973
 protein coding gene Chr11:17727885-17791512 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017920
 protein coding gene Chr11:19597181-19665177 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018497
 protein coding gene Chr11:17655136-17710135 (-)
PWK/PhJ MGP_PWKPhJ_G0017159
 protein coding gene Chr11:16890450-16970146 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016957
 protein coding gene Chr11:17367081-17420531 (-)
WSB/EiJ MGP_WSBEiJ_G0017433
 protein coding gene Chr11:17316750-17370934 (-)



Homology
more
  • Human Ortholog
    ACTR2, actin related protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACTR2, actin related protein 2
  • Synonyms
    ARP2
  • Links
    NCBI Gene ID: 10097
    neXtProt AC: NX_P61160
    UniProt: P61160

  • Chr Location
    2p14; chr2:65227788-65271253 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    13 phenotype references
Mice heterozygous for this mutation exhibit modifies lethality associated with F5 null Tfpi heterozygous mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    16
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020152 Ensembl Gene Model | MGI Sequence Detail 50610 C57BL/6J ±  kb
transcript ENSMUST00000000137 Ensembl | MGI Sequence Detail 3631 Not Applicable  
polypeptide ENSMUSP00000000137 Ensembl | MGI Sequence Detail 394 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 18
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1289149, MGI:2144001
References
more
  • Summaries
    All 69
    Developmental Gene Expression 6
    Gene Ontology 14
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:322355 Longatti A, et al., Arhgap22 Disruption Leads to RAC1 Hyperactivity Affecting Hippocampal Glutamatergic Synapses and Cognition in Mice. Mol Neurobiol. 2021 Dec;58(12):6092-6110
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory