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Lrrk2 Gene Detail
Summary
  • Symbol
    Lrrk2
  • Name
    leucine-rich repeat kinase 2
  • Synonyms
    4921513O20Rik, 9330188B09Rik, cI-46, D630001M17Rik, LOC381026
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913975
    NCBI Gene: 66725
  • Alliance
    gene page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:91557378-91700323 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 46.07 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5009 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913975
 protein coding gene Chr15:91556994-91700327 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022249
 protein coding gene Chr15:92994217-93150786 (+)
A/J MGP_AJ_G0022208
 protein coding gene Chr15:89396485-89549433 (+)
AKR/J MGP_AKRJ_G0022183
 protein coding gene Chr15:92046349-92200589 (+)
BALB/cJ MGP_BALBcJ_G0022214
 protein coding gene Chr15:89525719-89670200 (+)
C3H/HeJ MGP_C3HHeJ_G0021984
 protein coding gene Chr15:92059750-92214568 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022659
 protein coding gene Chr15:96390668-96547033 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020185
 protein coding gene Chr15:85529382-85670621 (+)
CAST/EiJ MGP_CASTEiJ_G0021506
 protein coding gene Chr15:92888108-93034012 (+)
CBA/J MGP_CBAJ_G0021951
 protein coding gene Chr15:99622645-99794961 (+)
DBA/2J MGP_DBA2J_G0022078
 protein coding gene Chr15:88835507-88985313 (+)
FVB/NJ MGP_FVBNJ_G0022057
 protein coding gene Chr15:87880227-88027271 (+)
LP/J MGP_LPJ_G0022149
 protein coding gene Chr15:93127343-93281936 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022077
 protein coding gene Chr15:103996867-104164435 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022674
 protein coding gene Chr15:92160768-92316152 (+)
PWK/PhJ MGP_PWKPhJ_G0021247
 protein coding gene Chr15:88901569-89048487 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021081
 protein coding gene Chr15:91897639-92045056 (+)
WSB/EiJ MGP_WSBEiJ_G0021555
 protein coding gene Chr15:92616351-92769151 (+)



Homology
more
  • Human Ortholog
    LRRK2, leucine rich repeat kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRRK2, leucine rich repeat kinase 2
  • Synonyms
    AURA17, DARDARIN, PARK8, RIPK7, ROCO2
  • Links
    NCBI Gene ID: 120892
    neXtProt AC: NX_Q5S007
    UniProt: Q5S007

  • Chr Location
    12q12
Human Diseases
more
  • Diseases
    1 with Lrrk2 mouse models; 5 with human LRRK2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 20 alleles in 15 genetic backgrounds
    7 phenotypes from multigenic genotypes
    169 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    312
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1224
  • Tissues
    250
  • cDNA Data
    29
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036273 Ensembl Gene Model | MGI Sequence Detail 142946 C57BL/6J ±  kb
    transcript ENSMUST00000060642 Ensembl | MGI Sequence Detail 8275 Not Applicable  
    polypeptide ENSMUSP00000052584 Ensembl | MGI Sequence Detail 2527 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 30
      Primer pair 13

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1930800, MGI:2442391, MGI:2685773
    References
    more
    • Summaries
      All 279
      Developmental Gene Expression 6
      Diseases 2
      Gene Ontology 39
      Phenotypes 169
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:354845 Heaton GR, et al., Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant. bioRxiv. 2024 Sep 5;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory