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Emc2 Gene Detail
Summary
  • Symbol
    Emc2
  • Name
    ER membrane protein complex subunit 2
  • Synonyms
    4921531G14Rik, Ttc35
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913986
    NCBI Gene: 66736
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:43340625-43391159 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.75 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    846 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913986
 protein coding gene Chr15:43340603-43391174 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021826
 protein coding gene Chr15:42074762-42118303 (+)
A/J MGP_AJ_G0021786
 protein coding gene Chr15:40451344-40496384 (+)
AKR/J MGP_AKRJ_G0021767
 protein coding gene Chr15:41662137-41703289 (+)
BALB/cJ MGP_BALBcJ_G0021793
 protein coding gene Chr15:40530550-40576580 (+)
C3H/HeJ MGP_C3HHeJ_G0021567
 protein coding gene Chr15:41560698-41615015 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022232
 protein coding gene Chr15:43677482-43726454 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019769
 protein coding gene Chr15:38041030-38083921 (+)
CAST/EiJ MGP_CASTEiJ_G0021084
 protein coding gene Chr15:42100690-42143746 (+)
CBA/J MGP_CBAJ_G0021536
 protein coding gene Chr15:45212543-45259738 (+)
DBA/2J MGP_DBA2J_G0021660
 protein coding gene Chr15:40275098-40320438 (+)
FVB/NJ MGP_FVBNJ_G0021638
 protein coding gene Chr15:39593800-39637165 (+)
LP/J MGP_LPJ_G0021730
 protein coding gene Chr15:41862414-41904612 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021662
 protein coding gene Chr15:48334925-48389196 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022255
 protein coding gene Chr15:41839311-41884717 (+)
PWK/PhJ MGP_PWKPhJ_G0020829
 protein coding gene Chr15:40316302-40446240 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020666
 protein coding gene Chr15:41507991-41560899 (+)
WSB/EiJ MGP_WSBEiJ_G0021139
 protein coding gene Chr15:41731714-41779737 (+)



Homology
more
  • Human Ortholog
    EMC2, ER membrane protein complex subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EMC2, ER membrane protein complex subunit 2
  • Synonyms
    KIAA0103, TTC35
  • Links
    NCBI Gene ID: 9694
    neXtProt AC: NX_Q15006
    UniProt: Q15006

  • Chr Location
    8q23.1; chr8:108443601-108489196 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
  • All Mutations and Alleles
    20
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    1
  • Gene trapped
    15
  • Targeted
    2
  • Genomic Mutations
    2 involving Emc2
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    18 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    80
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022337 Ensembl Gene Model | MGI Sequence Detail 50535 C57BL/6J ±  kb
transcript ENSMUST00000022962 Ensembl | MGI Sequence Detail 1231 Not Applicable  
polypeptide ENSMUSP00000022962 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    cDNA 80

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146165, MGI:2146208
References
more
  • Summaries
    All 37
    Gene Ontology 6
    Phenotypes 11
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:320079 Guna A, et al., The ER membrane protein complex is a transmembrane domain insertase. Science. 2018 Jan 26;359(6374):470-473
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory