Rcc1 MGI Mouse Gene Detail - MGI:1913989 - regulator of chromosome condensation 1

Symbol

Rcc1
Name

regulator of chromosome condensation 1
Synonyms

4931417M11Rik, Chc1

Feature Type

protein coding gene
IDs

MGI:1913989
NCBI Gene: 100088
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr4:132059230-132073061 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 65.20 cM
Mapping Data

2 experiments

SNPs within 2kb

432 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913989	protein coding gene	Chr4:132059230-132080916 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028869	protein coding gene	Chr4:134474612-134499495 (-)
A/J	MGP_AJ_G0028828	protein coding gene	Chr4:128888448-128910103 (-)
AKR/J	MGP_AKRJ_G0028781	protein coding gene	Chr4:132507343-132529356 (-)
BALB/cJ	MGP_BALBcJ_G0028851	protein coding gene	Chr4:129499091-129522227 (-)
C3H/HeJ	MGP_C3HHeJ_G0028565	protein coding gene	Chr4:132765774-132790922 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029293	protein coding gene	Chr4:139327490-139349053 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026564	protein coding gene	Chr4:121965225-121985947 (-)
CAST/EiJ	MGP_CASTEiJ_G0027998	protein coding gene	Chr4:130840613-130867131 (-)
CBA/J	MGP_CBAJ_G0028531	protein coding gene	Chr4:142899470-142924193 (-)
DBA/2J	MGP_DBA2J_G0028680	protein coding gene	Chr4:129311148-129333242 (-)
FVB/NJ	MGP_FVBNJ_G0028647	protein coding gene	Chr4:128159656-128181946 (-)
LP/J	MGP_LPJ_G0028781	protein coding gene	Chr4:134631635-134655445 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028673	protein coding gene	Chr4:147492499-147514199 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029331	protein coding gene	Chr4:132911570-132934127 (-)
PWK/PhJ	MGP_PWKPhJ_G0027719	protein coding gene	Chr4:125990985-126013663 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027545	protein coding gene	Chr4:128783972-128807303 (-)
WSB/EiJ	MGP_WSBEiJ_G0028078	protein coding gene	Chr4:133097515-133119140 (-)

Human Ortholog

RCC1, regulator of chromosome condensation 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RCC1, regulator of chromosome condensation 1
Synonyms

CHC1, RCC1-I
Links

HGNC:1913

NCBI Gene ID: 1104

neXtProt AC: NX_P18754

UniProt: P18754
Chr Location

1p35.3; chr1:28505943-28539300 (+) GRCh38

MGI Vertebrate Homology

Rcc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RCC1
Gene Tree

Rcc1

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

19
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Rcc1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

121 strains or lines available

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All GO Annotations

31
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

794
Tissues

53
cDNA Data

144
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rcc1

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All Sequences

59
RefSeq

4
UniProt

5
CCDS

CCDS18723.1, CCDS57303.1

Ensembl

ENSMUSG00000028896 (Evidence)
NCBI Gene

100088

			Length	Strain/Species	Flank
genomic	100088	NCBI Gene Model \| MGI Sequence Detail	13832	C57BL/6J	± kb
transcript	NM_001197082	RefSeq \| MGI Sequence Detail	2332	C57BL/6
polypeptide	Q8VE37	UniProt \| EBI \| MGI Sequence Detail	421	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000013833 regulator of chromosome condensation

(term hierarchy)
InterPro Domains

IPR051553 Ran GTPase-activating

IPR009091 Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

IPR000408 Regulator of chromosome condensation, RCC1

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All nucleic 145

cDNA 144

Primer pair 1

Microarray probesets 4

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MGI:2140246

Summaries

All 47

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 15
Earliest

J:34518 Kerr SM, et al., Ott, a mouse X-linked multigene family expressed specifically during meiosis. Hum Mol Genet. 1996 Aug;5(8):1139-48
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rcc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr1322	Chr4:132073048-132073053 (-)	10 bp
Tssr43661	Chr4:132073026-132073029 (-)	33 bp
Tssr43660	Chr4:132072997-132073019 (-)	53 bp
Tssr1321	Chr4:132072974-132072984 (-)	82 bp
Tssr43659	Chr4:132059859-132059872 (-)	13,195 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24