Ube2w MGI Mouse Gene Detail - MGI:1914049 - ubiquitin-conjugating enzyme E2W (putative)

Symbol

Ube2w
Name

ubiquitin-conjugating enzyme E2W (putative)
Synonyms

6130401J04Rik

Feature Type

protein coding gene
IDs

MGI:1914049
NCBI Gene: 66799
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:16611012-16689676 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 5.10 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

2070 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914049	protein coding gene	Chr1:16611012-16689713 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015856	protein coding gene	Chr1:14043625-14129823 (-)
A/J	MGP_AJ_G0015837	protein coding gene	Chr1:13869582-13950824 (-)
AKR/J	MGP_AKRJ_G0015796	protein coding gene	Chr1:13888238-13974307 (-)
BALB/cJ	MGP_BALBcJ_G0015793	protein coding gene	Chr1:13605684-13684603 (-)
C3H/HeJ	MGP_C3HHeJ_G0015627	protein coding gene	Chr1:13921959-14016069 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016247	protein coding gene	Chr1:14655072-14745580 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013968	protein coding gene	Chr1:12482044-12565035 (-)
CAST/EiJ	MGP_CASTEiJ_G0015208	protein coding gene	Chr1:13990326-14081975 (-)
CBA/J	MGP_CBAJ_G0015600	protein coding gene	Chr1:15006382-15095315 (-)
DBA/2J	MGP_DBA2J_G0015699	protein coding gene	Chr1:13479097-13558546 (-)
FVB/NJ	MGP_FVBNJ_G0015704	protein coding gene	Chr1:13270575-13348258 (-)
LP/J	MGP_LPJ_G0015771	protein coding gene	Chr1:14252700-14338721 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015723	protein coding gene	Chr1:15631065-15714934 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016294	protein coding gene	Chr1:13862676-13945356 (-)
PWK/PhJ	MGP_PWKPhJ_G0014992	protein coding gene	Chr1:13250034-13334106 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014773	protein coding gene	Chr1:14048256-14139055 (-)
WSB/EiJ	MGP_WSBEiJ_G0015271	protein coding gene	Chr1:13787304-13874460 (-)

Human Ortholog

UBE2W, ubiquitin conjugating enzyme E2 W

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

UBE2W, ubiquitin conjugating enzyme E2 W
Synonyms

UBC-16, UBC16
Links

HGNC:25616

NCBI Gene ID: 55284

neXtProt AC: NX_Q96B02

UniProt: Q96B02
Chr Location

8q21.11; chr8:73780096-73878910 (-) GRCh38

MGI Vertebrate Homology

Ube2w stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: UBE2W
Gene Tree

Ube2w

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

1
Gene trapped

10
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial prenatal, neonatal and early postnatal lethality, reduced male fertility and skin defects.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ube2w

ZFIN ube2wa

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All Sequences

65
RefSeq

13
UniProt

3
CCDS

CCDS48224.3, CCDS87815.1

Ensembl

ENSMUSG00000025939 (Evidence)
NCBI Gene

66799

			Length	Strain/Species	Flank
genomic	66799	NCBI Gene Model \| MGI Sequence Detail	78665	C57BL/6J	± kb
transcript	NM_025773	RefSeq \| MGI Sequence Detail	3092	C57BL/6
polypeptide	Q8VDW4	UniProt \| EBI \| MGI Sequence Detail	151	Not Applicable

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UniProt

3 Sequences
EC

2.3.2.23, 2.3.2.25
InterPro Domains

IPR050113 Ubiquitin-conjugating enzyme

IPR000608 Ubiquitin-conjugating enzyme E2

IPR016135 Ubiquitin-conjugating enzyme/RWD-like

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All nucleic 19

cDNA 19

Microarray probesets 7

Summaries

All 37

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ube2w:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr11047	Chr1:16689661-16689670 (-)	10 bp
Tssr11046	Chr1:16689527-16689538 (-)	143 bp
Tssr11045	Chr1:16689469-16689526 (-)	178 bp
Tssr11044	Chr1:16685726-16685730 (-)	3,948 bp
Tssr11043	Chr1:16649345-16649356 (-)	40,325 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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