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Trp53rkb Gene Detail
Summary
  • Symbol
    Trp53rkb
  • Name
    transformation related protein 53 regulating kinase B
  • Synonyms
    4933401B08Rik, 5630401H01Rik, MGC:2882, mNori-2p, Nori-2, PRPK, Trp53rk
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914050
    NCBI Gene: 76367
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:166634451-166641425 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 87.22 cM, cytoband H3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914050
 protein coding gene Chr2:166634379-166641425 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026902
 protein coding gene Chr2:172473092-172480738 (+)
A/J MGP_AJ_G0026868
 protein coding gene Chr2:165392057-165400766 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0026877
 protein coding gene Chr2:165743408-165750595 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0027325
 protein coding gene Chr2:177481053-177490990 (+)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0026734
 protein coding gene Chr2:164523354-164530972 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0026836
 protein coding gene Chr2:172503404-172510885 (+)
NOD/ShiLtJ no annotation
NZO/HlLtJ MGP_NZOHlLtJ_G0027381
 protein coding gene Chr2:170213521-170222443 (+)
PWK/PhJ MGP_PWKPhJ_G0025814
 protein coding gene Chr2:164158471-164165785 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025616
 protein coding gene Chr2:169168132-169176647 (+)
WSB/EiJ MGP_WSBEiJ_G0026150
 protein coding gene Chr2:171123439-171135592 (+)



Homology
more
  • Human Ortholog
    TP53RK, TP53 regulating kinase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TP53RK, TP53 regulating kinase
  • Synonyms
    BUD32, C20orf64, dJ101A2, GAMOS4, Nori-2, Nori-2p, PRPK, TPRKB
  • Links
    NCBI Gene ID: 112858
    neXtProt AC: NX_Q96S44
    UniProt: Q96S44

  • Chr Location
    20q13.12; chr20:46684365-46689444 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TP53RK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    42
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    26
  • cDNA Data
    10
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042854 Ensembl Gene Model | MGI Sequence Detail 6975 C57BL/6J ±  kb
transcript ENSMUST00000151826 Ensembl | MGI Sequence Detail 4426 Not Applicable  
polypeptide ENSMUSP00000115353 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 7
Other
Accession IDs
less
MGI:1923617
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory