Tmtc2 MGI Mouse Gene Detail - MGI:1914057 - transmembrane and tetratricopeptide repeat containing 2

Symbol

Tmtc2
Name

transmembrane and tetratricopeptide repeat containing 2
Synonyms

8430438D04Rik, D330034A10Rik

Feature Type

protein coding gene
IDs

MGI:1914057
NCBI Gene: 278279
Alliance

gene page
Transcription Start Sites

17 TSS

Sequence Map

Chr10:105023524-105410312 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 54.72 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

12872 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914057	protein coding gene	Chr10:105023524-105410340 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017702	protein coding gene	Chr10:107268818-107676834 (-)
A/J	MGP_AJ_G0017679	protein coding gene	Chr10:103287756-103678680 (-)
AKR/J	MGP_AKRJ_G0017641	protein coding gene	Chr10:106292681-106707172 (-)
BALB/cJ	MGP_BALBcJ_G0017643	protein coding gene	Chr10:103668794-104071792 (-)
C3H/HeJ	MGP_C3HHeJ_G0017468	protein coding gene	Chr10:106327637-106741118 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018100	protein coding gene	Chr10:111012544-111430173 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015779	protein coding gene	Chr10:98336115-98717959 (-)
CAST/EiJ	MGP_CASTEiJ_G0017029	protein coding gene	Chr10:106428305-106862624 (-)
CBA/J	MGP_CBAJ_G0017437	protein coding gene	Chr10:115295523-115730580 (-)
DBA/2J	MGP_DBA2J_G0017542	protein coding gene	Chr10:102392394-102786145 (-)
FVB/NJ	MGP_FVBNJ_G0017536	protein coding gene	Chr10:101473395-101867522 (-)
LP/J	MGP_LPJ_G0017616	protein coding gene	Chr10:107889424-108305475 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017566	protein coding gene	Chr10:117586784-118025342 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018138	protein coding gene	Chr10:106252848-106668851 (-)
PWK/PhJ	MGP_PWKPhJ_G0016811	protein coding gene	Chr10:102466775-102862799 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016601	protein coding gene	Chr10:104988105-105422572 (-)
WSB/EiJ	MGP_WSBEiJ_G0017089	protein coding gene	Chr10:106363466-106780330 (-)

Human Ortholog

TMTC2, transmembrane O-mannosyltransferase targeting cadherins 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMTC2, transmembrane O-mannosyltransferase targeting cadherins 2
Synonyms

IBDBP1
Links

HGNC:25440

NCBI Gene ID: 160335

neXtProt AC: NX_Q8N394

UniProt: Q8N394
Chr Location

12q21.31; chr12:82686880-83134870 (+) GRCh38

MGI Vertebrate Homology

Tmtc2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMTC2
Gene Tree

Tmtc2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Genomic Mutations

1 involving Tmtc2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

12
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1054
Tissues

40
cDNA Data

32
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmtc2

ZFIN tmtc2a

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All Sequences

51
RefSeq

6
UniProt

2
CCDS

CCDS24157.1

Ensembl

ENSMUSG00000036019 (Evidence)
NCBI Gene

278279

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036019	Ensembl Gene Model \| MGI Sequence Detail	386789	C57BL/6J	± kb
transcript	ENSMUST00000061506	Ensembl \| MGI Sequence Detail	5629	Not Applicable
polypeptide	ENSMUSP00000061919	Ensembl \| MGI Sequence Detail	836	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000032814 protein O-mannosyl-transferase TMTC2

(term hierarchy)
EC

2.4.1.109
InterPro Domains

IPR052384 O-mannosyl-transferase TMTC

IPR013618 Protein O-mannosyl-transferase TMTC, DUF1736

IPR011990 Tetratricopeptide-like helical domain superfamily

IPR019734 Tetratricopeptide repeat

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All nucleic 32

cDNA 32

Microarray probesets 4

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MGI:2444719

Summaries

All 36

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 13
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tmtc2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99178	Chr10:105410327-105410330 (-)	-17 bp
Tssr99177	Chr10:105410297-105410312 (-)	7 bp
Tssr99176	Chr10:105410282-105410294 (-)	24 bp
Tssr99175	Chr10:105410250-105410268 (-)	53 bp
Tssr3343	Chr10:105410242-105410243 (-)	69 bp
Tssr99174	Chr10:105410029-105410104 (-)	245 bp
Tssr99173	Chr10:105404113-105404117 (-)	6,197 bp
Tssr99172	Chr10:105394806-105394824 (-)	15,497 bp
Tssr99171	Chr10:105368438-105368442 (-)	41,872 bp
Tssr99170	Chr10:105357865-105357878 (-)	52,440 bp
Tssr99169	Chr10:105357627-105357656 (-)	52,670 bp
Tssr99168	Chr10:105309999-105310004 (-)	100,310 bp
Tssr99165	Chr10:105151563-105151570 (-)	258,745 bp
Tssr99164	Chr10:105151547-105151554 (-)	258,761 bp
Tssr99163	Chr10:105149904-105149908 (-)	260,406 bp
Tssr99162	Chr10:105132406-105132410 (-)	277,904 bp
Tssr99161	Chr10:105031847-105031851 (-)	378,463 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24