Bcl2l14 MGI Mouse Gene Detail - MGI:1914063

Symbol

Bcl2l14
Name

BCL2 like 14
Synonyms

4930452K23Rik, 4933405K19Rik, 9030625M01Rik, Bcl-G

Feature Type

protein coding gene
IDs

MGI:1914063
NCBI Gene: 66813
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr6:134373292-134415687 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 65.22 cM
Mapping Data

3 experiments

SNPs within 2kb

1502 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914063	protein coding gene	Chr6:134373281-134415699 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0031403	protein coding gene	Chr6:138652404-138695878 (+)
A/J	MGP_AJ_G0031379	protein coding gene	Chr6:133227058-133269839 (+)
AKR/J	MGP_AKRJ_G0031306	protein coding gene	Chr6:137260594-137305081 (+)
BALB/cJ	MGP_BALBcJ_G0031385	protein coding gene	Chr6:133039250-133082212 (+)
C3H/HeJ	MGP_C3HHeJ_G0031107	protein coding gene	Chr6:137312596-137355913 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031845	protein coding gene	Chr6:142416414-142459073 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028977	protein coding gene	Chr6:132378602-132421629 (+)
CAST/EiJ	MGP_CASTEiJ_G0030476	protein coding gene	Chr6:136701642-136743037 (+)
CBA/J	MGP_CBAJ_G0031066	protein coding gene	Chr6:147737461-147785691 (+)
DBA/2J	MGP_DBA2J_G0031224	protein coding gene	Chr6:132074883-132117933 (+)
FVB/NJ	MGP_FVBNJ_G0031174	protein coding gene	Chr6:130993481-131036031 (+)
LP/J	MGP_LPJ_G0031308	protein coding gene	Chr6:138766985-138809677 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031214	protein coding gene	Chr6:151795688-151839742 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031878	protein coding gene	Chr6:137007174-137052111 (+)
PWK/PhJ	MGP_PWKPhJ_G0030201	protein coding gene	Chr6:130547862-130591470 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0030025	protein coding gene	Chr6:135160319-135203197 (+)
WSB/EiJ	MGP_WSBEiJ_G0030567	protein coding gene	Chr6:137635360-137678424 (+)

Human Ortholog

BCL2L14, BCL2 like 14

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BCL2L14, BCL2 like 14
Synonyms

BCLG
Links

HGNC:16657

NCBI Gene ID: 79370

neXtProt AC: NX_Q9BZR8

UniProt: Q9BZR8
Chr Location

12p13.2; chr12:12049844-12211084 (+) GRCh38

MGI Vertebrate Homology

Bcl2l14 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: BCL2L14
Gene Tree

Bcl2l14

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
1 phenotype from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Endonuclease-mediated

2
Gene trapped

2
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele show accelerated progression of induced colitis-associated cancer.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

769
Tissues

10
cDNA Data

41
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bcl2l14

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All Sequences

48
RefSeq

4
UniProt

2
CCDS

CCDS20636.1

Ensembl

ENSMUSG00000030200 (Evidence)
NCBI Gene

66813

			Length	Strain/Species	Flank
genomic	66813	NCBI Gene Model \| MGI Sequence Detail	42396	C57BL/6J	± kb
transcript	NM_025778	RefSeq \| MGI Sequence Detail	2220	C57BL/6
polypeptide	Q9CPT0	UniProt \| EBI \| MGI Sequence Detail	328	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000004696 apoptosis facilitator Bcl-2-like protein 14

(term hierarchy)
InterPro Domains

IPR002475 Bcl2-like

IPR036834 Bcl-2-like superfamily

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All nucleic 43

cDNA 42

Primer pair 1

Microarray probesets 7

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MGI:1889821, MGI:1914796, MGI:1922120

Summaries

All 35

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:296081 Nguyen PM, et al., Loss of Bcl-G, a Bcl-2 family member, augments the development of inflammation-associated colorectal cancer. Cell Death Differ. 2020 Feb;27(2):742-757

TSS for Bcl2l14:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr59236	Chr6:134373279-134373282 (+)	-11 bp
Tssr59237	Chr6:134373284-134373301 (+)	1 bp
Tssr59238	Chr6:134391386-134391398 (+)	18,100 bp
Tssr59239	Chr6:134391399-134391421 (+)	18,118 bp
Tssr59240	Chr6:134391422-134391448 (+)	18,143 bp
Tssr59241	Chr6:134391453-134391475 (+)	18,172 bp
Tssr59242	Chr6:134408823-134408830 (+)	35,535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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