Fbxo25 MGI Mouse Gene Detail - MGI:1914072

Symbol

Fbxo25
Name

F-box protein 25
Synonyms

9130015I06Rik, Fbx25

Feature Type

protein coding gene
IDs

MGI:1914072
NCBI Gene: 66822
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:13957803-13990522 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 6.42 cM
Mapping Data

2 experiments

SNPs within 2kb

926 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914072	protein coding gene	Chr8:13957667-13992862 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033391	protein coding gene	Chr8:11283305-11313570 (+)
A/J	MGP_AJ_G0033372	protein coding gene	Chr8:10878234-10912391 (+)
AKR/J	MGP_AKRJ_G0033302	protein coding gene	Chr8:11153570-11186026 (+)
BALB/cJ	MGP_BALBcJ_G0033372	protein coding gene	Chr8:10983737-11015692 (+)
C3H/HeJ	MGP_C3HHeJ_G0033085	protein coding gene	Chr8:11384524-11420573 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033884	protein coding gene	Chr8:11653188-11690428 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030851	protein coding gene	Chr8:10313772-10347362 (+)
CAST/EiJ	MGP_CASTEiJ_G0032407	protein coding gene	Chr8:11170319-11204198 (+)
CBA/J	MGP_CBAJ_G0033058	protein coding gene	Chr8:12145287-12177791 (+)
DBA/2J	MGP_DBA2J_G0033212	protein coding gene	Chr8:10821068-10851448 (+)
FVB/NJ	MGP_FVBNJ_G0033160	protein coding gene	Chr8:10831333-10863679 (+)
LP/J	MGP_LPJ_G0033305	protein coding gene	Chr8:11249048-11281546 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033197	protein coding gene	Chr8:12389347-12428913 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033901	protein coding gene	Chr8:11249771-11284519 (+)
PWK/PhJ	MGP_PWKPhJ_G0032120	protein coding gene	Chr8:10873592-10905238 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031961	protein coding gene	Chr8:11111563-11142940 (+)
WSB/EiJ	MGP_WSBEiJ_G0032523	protein coding gene	Chr8:11275944-11306437 (+)

Human Ortholog

FBXO25, F-box protein 25

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FBXO25, F-box protein 25
Synonyms

FBX25
Links

HGNC:13596

NCBI Gene ID: 26260

neXtProt AC: NX_Q8TCJ0

UniProt: Q8TCJ0
Chr Location

8p23.3; chr8:406428-477967 (+) GRCh38

MGI Vertebrate Homology

Fbxo25 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FBXO25
Gene Tree

Fbxo25

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Phenotype Summary

16 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Gene trapped

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

11
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

803
Tissues

33
cDNA Data

48
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fbxo25

ZFIN fbxo25

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All Sequences

49
RefSeq

8
UniProt

4
CCDS

CCDS22118.1, CCDS85507.1

Ensembl

ENSMUSG00000038365 (Evidence)
NCBI Gene

66822

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038365	Ensembl Gene Model \| MGI Sequence Detail	32720	C57BL/6J	± kb
transcript	ENSMUST00000209913	Ensembl \| MGI Sequence Detail	2035	Not Applicable
polypeptide	ENSMUSP00000147467	Ensembl \| MGI Sequence Detail	365	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007397 F-box only protein 25

(term hierarchy)
InterPro Domains

IPR036047 F-box-like domain superfamily

IPR040394 F-box only protein 25/32

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All nucleic 50

cDNA 49

Other 1

Microarray probesets 3

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MGI:2142606

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 5

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fbxo25:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76432	Chr8:13957736-13957745 (+)	-62 bp
Tssr76433	Chr8:13957748-13957816 (+)	-21 bp
Tssr76434	Chr8:13957827-13957837 (+)	29 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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