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Nacc1 Gene Detail
Summary
  • Symbol
    Nacc1
  • Name
    nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
  • Synonyms
    2010001H03Rik, 4930511N13Rik, Btbd14b, Nac1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914080
    NCBI Gene: 66830
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85397106-85414528 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914080
 protein coding gene Chr8:85397106-85414531 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033865
 protein coding gene Chr8:85580310-85600177 (-)
A/J MGP_AJ_G0033848
 protein coding gene Chr8:82211783-82229109 (-)
AKR/J MGP_AKRJ_G0033774
 protein coding gene Chr8:84646762-84663939 (-)
BALB/cJ MGP_BALBcJ_G0033841
 protein coding gene Chr8:82332655-82352612 (-)
C3H/HeJ MGP_C3HHeJ_G0033551
 protein coding gene Chr8:85261681-85269110 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034361
 protein coding gene Chr8:88869968-88876492 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031303
 protein coding gene Chr8:76005427-76022849 (-)
CAST/EiJ MGP_CASTEiJ_G0032881
 protein coding gene Chr8:84687091-84706702 (-)
CBA/J MGP_CBAJ_G0033527
 protein coding gene Chr8:91917686-91921920 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0033628
 protein coding gene Chr8:80787943-80795350 (-)
LP/J MGP_LPJ_G0033772
 protein coding gene Chr8:85696499-85712634 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033670
 protein coding gene Chr8:94460193-94479645 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034378
 protein coding gene Chr8:84634377-84654102 (-)
PWK/PhJ MGP_PWKPhJ_G0032585
 protein coding gene Chr8:81086313-81095627 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032421
 protein coding gene Chr8:83445301-83465031 (-)
WSB/EiJ MGP_WSBEiJ_G0032994
 protein coding gene Chr8:85062265-85067279 (-)



Homology
more
  • Human Ortholog
    NACC1, nucleus accumbens associated 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NACC1, nucleus accumbens associated 1
  • Synonyms
    BEND8, BTBD14B, BTBD30, NAC-1, NAC1, NECFM
  • Links
    NCBI Gene ID: 112939
    neXtProt AC: NX_Q96RE7
    UniProt: Q96RE7

  • Chr Location
    19p13.13; chr19:13116852-13141147 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 3 genetic backgrounds
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased sensitivity to cocaine and amphetamine. Mice homozygous for a different knock-out allele exhibit thoracic vertebral transformation and loss of the sixth lumbar vertebrae with decreaed rib number and reduced chondrocyte migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    14
  • cDNA Data
    7
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66830 NCBI Gene Model | MGI Sequence Detail 17423 C57BL/6J ±  kb
    transcript NM_025788 RefSeq | MGI Sequence Detail 4332 ZRU/MplStud  
    polypeptide Q7TSZ8 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 8
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917610
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 43
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:354196 Deehan MA, et al., Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction. J Neurosci. 2024 Apr 3;44(14)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory