Acot13 MGI Mouse Gene Detail - MGI:1914084

Symbol

Acot13
Name

acyl-CoA thioesterase 13
Synonyms

0610006O17Rik, Them2

Feature Type

protein coding gene
IDs

MGI:1914084
NCBI Gene: 66834
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr13:25001938-25015472 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 10.69 cM, cytoband A3.2
Mapping Data

2 experiments

SNPs within 2kb

595 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914084	protein coding gene	Chr13:25001931-25015523 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020381	protein coding gene	Chr13:22301791-22322059 (-)
A/J	MGP_AJ_G0020330	protein coding gene	Chr13:21903447-21917154 (-)
AKR/J	MGP_AKRJ_G0020310	protein coding gene	Chr13:22143785-22157145 (-)
BALB/cJ	MGP_BALBcJ_G0020328	protein coding gene	Chr13:21879820-21893395 (-)
C3H/HeJ	MGP_C3HHeJ_G0020132	protein coding gene	Chr13:22223374-22238725 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020765	protein coding gene	Chr13:23109626-23123021 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018353	protein coding gene	Chr13:20622495-20630852 (-)
CAST/EiJ	MGP_CASTEiJ_G0019649	protein coding gene	Chr13:21930466-21943544 (-)
CBA/J	MGP_CBAJ_G0020086	protein coding gene	Chr13:23995811-24009858 (-)
DBA/2J	MGP_DBA2J_G0020212	protein coding gene	Chr13:21397925-21411307 (-)
FVB/NJ	MGP_FVBNJ_G0020196	protein coding gene	Chr13:21044250-21057858 (-)
LP/J	MGP_LPJ_G0020285	protein coding gene	Chr13:22614305-22627987 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020223	protein coding gene	Chr13:24246209-24263656 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020807	protein coding gene	Chr13:21989310-22003198 (-)
PWK/PhJ	MGP_PWKPhJ_G0019403	protein coding gene	Chr13:21420432-21434587 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019219	protein coding gene	Chr13:20815425-20828747 (-)
WSB/EiJ	MGP_WSBEiJ_G0019709	protein coding gene	Chr13:22155493-22171402 (-)

Human Ortholog

ACOT13, acyl-CoA thioesterase 13

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACOT13, acyl-CoA thioesterase 13
Synonyms

HT012, PNAS-27, THEM2
Links

HGNC:20999

NCBI Gene ID: 55856

neXtProt AC: NX_Q9NPJ3

UniProt: Q9NPJ3
Chr Location

6p22.3; chr6:24667035-24705065 (+) GRCh38

MGI Vertebrate Homology

Acot13 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACOT13
Gene Tree

Acot13

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Phenotype Summary

31 phenotypes from 1 allele in 2 genetic backgrounds
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Gene trapped

5
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Acot13
Incidental Mutations

CvDC
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit altered adaptive thermorgenesis, decreased body weight, reduced white adipose tissue and abnormal hepatic lipid and glucose metabolism, especially in mice fed a high fat diet.

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All GO Annotations

13
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

728
Tissues

3
cDNA Data

77
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acot13

ZFIN acot13

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All Sequences

37
RefSeq

2
UniProt

2
CCDS

CCDS26380.1

Ensembl

ENSMUSG00000006717 (Evidence)
NCBI Gene

66834

			Length	Strain/Species	Flank
genomic	66834	NCBI Gene Model \| MGI Sequence Detail	13535	C57BL/6J	± kb
transcript	NM_025790	RefSeq \| MGI Sequence Detail	686	C57BL/6
polypeptide	Q9CQR4	UniProt \| EBI \| MGI Sequence Detail	140	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000029260 acyl-coenzyme A thioesterase 13

(term hierarchy)
PDB

2CY9
EC

3.1.2.-, 3.1.2.2
InterPro Domains

IPR039298 Acyl-coenzyme A thioesterase 13

IPR029069 HotDog domain superfamily

IPR003736 Phenylacetic acid degradation-related domain

IPR006683 Thioesterase domain
GlyGen

Q9CQR4 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

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All nucleic 78

Genomic 1

cDNA 77

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 1

Gene Ontology 10

Phenotypes 23
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:282877 Bekeova C, et al., Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles. J Biol Chem. 2019 Dec 13;294(50):19034-19047

TSS for Acot13:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121816	Chr13:25015571-25015622 (-)	-125 bp
Tssr121815	Chr13:25015392-25015501 (-)	25 bp
Tssr121814	Chr13:25015336-25015391 (-)	108 bp
Tssr121813	Chr13:25015320-25015331 (-)	146 bp
Tssr121812	Chr13:25015305-25015316 (-)	161 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24