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Tcf25 Gene Detail
Summary
  • Symbol
    Tcf25
  • Name
    transcription factor 25 (basic helix-loop-helix)
  • Synonyms
    1100001J13Rik, 1810041K11Rik, D8Ertd325e, mKIAA1049, Nulp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914105
    NCBI Gene: 66855
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:124100492-124130574 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 72.10 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1071 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914105
 protein coding gene Chr8:124097511-124130913 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034253
 protein coding gene Chr8:126985552-127016826 (+)
A/J MGP_AJ_G0034233
 protein coding gene Chr8:121728353-121759835 (+)
AKR/J MGP_AKRJ_G0034160
 protein coding gene Chr8:125263958-125297554 (+)
BALB/cJ MGP_BALBcJ_G0034226
 protein coding gene Chr8:121930864-121961004 (+)
C3H/HeJ MGP_C3HHeJ_G0033937
 protein coding gene Chr8:125965560-125997367 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034746
 protein coding gene Chr8:131233507-131265712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031688
 protein coding gene Chr8:114544734-114577045 (+)
CAST/EiJ MGP_CASTEiJ_G0033265
 protein coding gene Chr8:126064154-126096431 (+)
CBA/J MGP_CBAJ_G0033910
 protein coding gene Chr8:136047536-136083262 (+)
DBA/2J MGP_DBA2J_G0034066
 protein coding gene Chr8:120896964-120927153 (+)
FVB/NJ MGP_FVBNJ_G0034010
 protein coding gene Chr8:120069025-120099549 (+)
LP/J MGP_LPJ_G0034156
 protein coding gene Chr8:127121871-127162491 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034057
 protein coding gene Chr8:138182349-138213680 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034765
 protein coding gene Chr8:125471854-125502751 (+)
PWK/PhJ MGP_PWKPhJ_G0032966
 protein coding gene Chr8:120732346-120762593 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032806
 protein coding gene Chr8:124186050-124221797 (+)
WSB/EiJ MGP_WSBEiJ_G0033381
 protein coding gene Chr8:126208146-126240273 (+)



Homology
more
  • Human Ortholog
    TCF25, transcription factor 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF25, transcription factor 25
  • Synonyms
    FKSG26, hKIAA1049, Hulp1, NULP1, PRO2620
  • Links
    NCBI Gene ID: 22980
    neXtProt AC: NX_Q9BQ70
    UniProt: Q9BQ70

  • Chr Location
    16q24.3; chr16:89873570-89913627 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display increased responses of the heart to induced stress.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    907
  • Tissues
    81
  • cDNA Data
    413
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001472 Ensembl Gene Model | MGI Sequence Detail 30083 C57BL/6J ±  kb
    transcript ENSMUST00000057934 Ensembl | MGI Sequence Detail 2738 Not Applicable  
    polypeptide ENSMUSP00000056485 Ensembl | MGI Sequence Detail 676 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 417
      Genomic 1
      cDNA 414
      Primer pair 1
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1196305, MGI:1919548
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 4
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory