Dnajc10 MGI Mouse Gene Detail - MGI:1914111 - DnaJ heat shock protein family (Hsp40) member C10

Symbol

Dnajc10
Name

DnaJ heat shock protein family (Hsp40) member C10
Synonyms

1200006L06Rik, D2Ertd706e, ERdj5, JPDI

Feature Type

protein coding gene
IDs

MGI:1914111
NCBI Gene: 66861
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr2:80145810-80184387 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 48.05 cM, cytoband D
Mapping Data

3 experiments

SNPs within 2kb

919 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914111	protein coding gene	Chr2:80145790-80184399 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025883	protein coding gene	Chr2:80888458-80928823 (+)
A/J	MGP_AJ_G0025860	protein coding gene	Chr2:77768832-77808034 (+)
AKR/J	MGP_AKRJ_G0025829	protein coding gene	Chr2:79805771-79844329 (+)
BALB/cJ	MGP_BALBcJ_G0025856	protein coding gene	Chr2:77903057-77944142 (+)
C3H/HeJ	MGP_C3HHeJ_G0025615	protein coding gene	Chr2:80041344-80080157 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026302	protein coding gene	Chr2:83272302-83310892 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023705	protein coding gene	Chr2:74991439-75029764 (+)
CAST/EiJ	MGP_CASTEiJ_G0025077	protein coding gene	Chr2:80470058-80511621 (+)
CBA/J	MGP_CBAJ_G0025596	protein coding gene	Chr2:86263929-86309677 (+)
DBA/2J	MGP_DBA2J_G0025727	protein coding gene	Chr2:77320540-77359727 (+)
FVB/NJ	MGP_FVBNJ_G0025689	protein coding gene	Chr2:76668191-76707164 (+)
LP/J	MGP_LPJ_G0025815	protein coding gene	Chr2:80750327-80789566 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025720	protein coding gene	Chr2:88148705-88187441 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026358	protein coding gene	Chr2:79972260-80013093 (+)
PWK/PhJ	MGP_PWKPhJ_G0024820	protein coding gene	Chr2:77260157-77299661 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024626	protein coding gene	Chr2:80216474-80257878 (+)
WSB/EiJ	MGP_WSBEiJ_G0025146	protein coding gene	Chr2:80596250-80634783 (+)

Human Ortholog

DNAJC10, DnaJ heat shock protein family (Hsp40) member C10

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DNAJC10, DnaJ heat shock protein family (Hsp40) member C10
Synonyms

ERdj5, JPDI, MTHr, PDIA19
Links

HGNC:24637

NCBI Gene ID: 54431

neXtProt AC: NX_Q8IXB1

UniProt: Q8IXB1
Chr Location

2q32.1; chr2:182716255-182794464 (+) GRCh38

MGI Vertebrate Homology

Dnajc10 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DNAJC10
Protein SuperFamily

DnaJ_homolog_subfam-C
Gene Tree

Dnajc10

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Phenotype Summary

7 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

3
Spontaneous

1
Targeted

7
Genomic Mutations

3 involving Dnajc10
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

44 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased endoplasmic reticulum stress in the salivary gland. Female homozygous mutant mice are smaller than controls.

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All GO Annotations

37
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

16

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dnajc10

ZFIN dnajc10

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All Sequences

61
RefSeq

3
UniProt

3
CCDS

CCDS38159.1

Ensembl

ENSMUSG00000027006 (Evidence)
NCBI Gene

66861

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027006	Ensembl Gene Model \| MGI Sequence Detail	38578	C57BL/6J	± kb
transcript	ENSMUST00000028392	Ensembl \| MGI Sequence Detail	4042	Not Applicable
polypeptide	ENSMUSP00000028392	Ensembl \| MGI Sequence Detail	793	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000006580 DnaJ homolog subfamily C member 10

(term hierarchy)
PDB

3APO, 3APQ, 3APS, 5AYK, 5AYL
EC

1.8.4.-
InterPro Domains

IPR036869 Chaperone J-domain superfamily

IPR001623 DnaJ domain

IPR021170 DnaJ homologue subfamily C member 10

IPR052460 Endoplasmic reticulum disulfide reductase

IPR035674 ERdj5, C-terminal thioredoxin domain

IPR035673 ERdj5, first thioredoxin domain

IPR017937 Thioredoxin, conserved site

IPR013766 Thioredoxin domain

IPR036249 Thioredoxin-like superfamily
GlyGen

Q9DC23 2 sites, 1 O-linked glycan (1 site)

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All nucleic 17

cDNA 16

Primer pair 1

Microarray probesets 5

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MGI:1289214

Summaries

All 51

Gene Ontology 8

Phenotypes 23
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dnajc10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18606	Chr2:80145805-80145855 (+)	20 bp
Tssr18607	Chr2:80145860-80145872 (+)	56 bp
Tssr18608	Chr2:80145879-80145890 (+)	75 bp
Tssr18609	Chr2:80146013-80146022 (+)	208 bp
Tssr18610	Chr2:80146047-80146088 (+)	258 bp
Tssr18611	Chr2:80147100-80147112 (+)	1,296 bp
Tssr18612	Chr2:80147171-80147185 (+)	1,368 bp
Tssr18613	Chr2:80147187-80147217 (+)	1,392 bp
Tssr18614	Chr2:80147223-80147224 (+)	1,414 bp
Tssr546	Chr2:80147310-80147327 (+)	1,509 bp
Tssr18615	Chr2:80147332-80147338 (+)	1,525 bp
Tssr18616	Chr2:80147348-80147368 (+)	1,548 bp
Tssr18617	Chr2:80147698-80147707 (+)	1,893 bp
Tssr18618	Chr2:80148360-80148368 (+)	2,554 bp
Tssr18619	Chr2:80148374-80148385 (+)	2,570 bp
Tssr18620	Chr2:80154728-80154732 (+)	8,920 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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