Bzw1 MGI Mouse Gene Detail - MGI:1914132 - basic leucine zipper and W2 domains 1

Symbol

Bzw1
Name

basic leucine zipper and W2 domains 1
Synonyms

1200015E15Rik, MGC:6434, mKIAA0005

Feature Type

protein coding gene
IDs

MGI:1914132
NCBI Gene: 66882
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:58432057-58446512 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 29.09 cM, cytoband C2
Mapping Data

1 experiment

SNPs within 2kb

325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914132	protein coding gene	Chr1:58432057-58446513 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016049	protein coding gene	Chr1:58252908-58270175 (+)
A/J	MGP_AJ_G0016032	protein coding gene	Chr1:56215801-56230381 (+)
AKR/J	MGP_AKRJ_G0015988	protein coding gene	Chr1:57734882-57749703 (+)
BALB/cJ	MGP_BALBcJ_G0015987	protein coding gene	Chr1:56252400-56267077 (+)
C3H/HeJ	MGP_C3HHeJ_G0015819	protein coding gene	Chr1:58001734-58019339 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016440	protein coding gene	Chr1:60601738-60616268 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014162	protein coding gene	Chr1:52147859-52160250 (+)
CAST/EiJ	MGP_CASTEiJ_G0015401	protein coding gene	Chr1:57248439-57264673 (+)
CBA/J	MGP_CBAJ_G0015791	protein coding gene	Chr1:62376425-62392033 (+)
DBA/2J	MGP_DBA2J_G0015892	protein coding gene	Chr1:55614831-55630263 (+)
FVB/NJ	MGP_FVBNJ_G0015894	protein coding gene	Chr1:54956534-54969057 (+)
LP/J	MGP_LPJ_G0015964	protein coding gene	Chr1:59151155-59167257 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015914	protein coding gene	Chr1:65382829-65398778 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016487	protein coding gene	Chr1:57710445-57724898 (+)
PWK/PhJ	MGP_PWKPhJ_G0015187	protein coding gene	Chr1:55003186-55020114 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0014968	protein coding gene	Chr1:57297090-57313745 (+)
WSB/EiJ	MGP_WSBEiJ_G0015464	protein coding gene	Chr1:57398949-57415103 (+)

Human Ortholog

BZW1, basic leucine zipper and W2 domains 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BZW1, basic leucine zipper and W2 domains 1
Synonyms

5MP2, BZAP45, Nbla10236
Links

HGNC:18380

NCBI Gene ID: 9689

neXtProt AC: NX_Q7L1Q6

UniProt: Q7L1Q6
Chr Location

2q33.1; chr2:200810594-200827338 (+) GRCh38

MGI Vertebrate Homology

Bzw1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: BZW1
Gene Tree

Bzw1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

38
Radiation induced

1
Genomic Mutations

2 involving Bzw1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

11
cDNA Data

609
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bzw1

ZFIN bzw1a, bzw1b

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All Sequences

91
RefSeq

4
UniProt

5
CCDS

CCDS14971.1

Ensembl

ENSMUSG00000051223 (Evidence)
NCBI Gene

66882

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051223	Ensembl Gene Model \| MGI Sequence Detail	14456	C57BL/6J	± kb
transcript	ENSMUST00000186949	Ensembl \| MGI Sequence Detail	1492	Not Applicable
polypeptide	ENSMUSP00000140319	Ensembl \| MGI Sequence Detail	451	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000004865 eIF5-mimic protein 2

(term hierarchy)
InterPro Domains

IPR016024 Armadillo-type fold

IPR043510 BZW1/2, W2 domain

IPR051245 eIF5-mimic translation initiation regulator

IPR003307 W2 domain

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All nucleic 610

cDNA 609

Primer pair 1

Microarray probesets 7

Summaries

All 39

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 14
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Bzw1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6765	Chr1:58431751-58431757 (+)	-303 bp
Tssr6766	Chr1:58432022-58432038 (+)	-27 bp
Tssr6767	Chr1:58432125-58432145 (+)	78 bp
Tssr6768	Chr1:58432278-58432306 (+)	235 bp
Tssr6769	Chr1:58432352-58432400 (+)	319 bp
Tssr6770	Chr1:58432630-58432641 (+)	579 bp
Tssr6771	Chr1:58432642-58432655 (+)	592 bp
Tssr6772	Chr1:58432660-58432681 (+)	614 bp
Tssr6773	Chr1:58445686-58445695 (+)	13,634 bp
Tssr6774	Chr1:58445958-58445983 (+)	13,914 bp
Tssr6775	Chr1:58445997-58446034 (+)	13,959 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24