Rnf128 MGI Mouse Gene Detail - MGI:1914139

Symbol

Rnf128
Name

ring finger protein 128
Synonyms

1300002C13Rik, GRAIL, Greul1

Feature Type

protein coding gene
IDs

MGI:1914139
NCBI Gene: 66889
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

ChrX:138464089-138573894 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 61.35 cM
Mapping Data

2 experiments

SNPs within 2kb

2325 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914139	protein coding gene	ChrX:138464065-138573894 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036124	protein coding gene	ChrX:137061287-137176607 (+)
A/J	MGP_AJ_G0036103	protein coding gene	ChrX:136441730-136560896 (+)
AKR/J	MGP_AKRJ_G0036027	protein coding gene	ChrX:140835372-140954003 (+)
BALB/cJ	MGP_BALBcJ_G0036092	protein coding gene	ChrX:134798555-134909787 (+)
C3H/HeJ	MGP_C3HHeJ_G0035801	protein coding gene	ChrX:137084137-137205332 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036617	protein coding gene	ChrX:141099508-141220756 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033442	protein coding gene	ChrX:128210165-128316116 (+)
CAST/EiJ	MGP_CASTEiJ_G0035092	protein coding gene	ChrX:117902986-118019685 (+)
CBA/J	MGP_CBAJ_G0035778	protein coding gene	ChrX:145400154-145528038 (+)
DBA/2J	MGP_DBA2J_G0035935	protein coding gene	ChrX:135631706-135742451 (+)
FVB/NJ	MGP_FVBNJ_G0035869	protein coding gene	ChrX:134863855-134971909 (+)
LP/J	MGP_LPJ_G0036027	protein coding gene	ChrX:138036458-138150303 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035906	protein coding gene	ChrX:152922746-153052409 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036653	protein coding gene	ChrX:136380807-136493152 (+)
PWK/PhJ	MGP_PWKPhJ_G0034785	protein coding gene	ChrX:114823961-114942797 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034612	protein coding gene	ChrX:118426245-118546916 (+)
WSB/EiJ	MGP_WSBEiJ_G0035227	protein coding gene	ChrX:134705940-134820623 (+)

Human Ortholog

RNF128, ring finger protein 128

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNF128, ring finger protein 128
Synonyms

GRAIL
Links

HGNC:21153

NCBI Gene ID: 79589

neXtProt AC: NX_Q8TEB7

UniProt: Q8TEB7
Chr Location

Xq22.3; chrX:106693794-106797016 (+) GRCh38

MGI Vertebrate Homology

Rnf128 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNF128
Gene Tree

Rnf128

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Phenotype Summary

30 phenotypes from 5 alleles in 6 genetic backgrounds
8 phenotypes from multigenic genotypes
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

4
Gene trapped

2
Targeted

7
Incidental Mutations

CvDC
Find Mice (IMSR)

10 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele dsiplay defects in naive, helper and anergic T cell states affecting survival, proliferation and cytokine secretion. Homozygotes for another null allele show impaired T cell tolerance and regulatory T cell function and increased susceptibility to autoimmune disease.

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All GO Annotations

19
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

878
Tissues

162
cDNA Data

93
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnf128

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All Sequences

46
RefSeq

4
UniProt

2
CCDS

CCDS30435.1, CCDS57776.1

Ensembl

ENSMUSG00000031438 (Evidence)
NCBI Gene

66889

			Length	Strain/Species	Flank
genomic	66889	NCBI Gene Model \| MGI Sequence Detail	109806	C57BL/6J	± kb
transcript	NM_023270	RefSeq \| MGI Sequence Detail	2764	C57BL/6
polypeptide	Q9D304	UniProt \| EBI \| MGI Sequence Detail	428	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014079 E3 ubiquitin-protein ligase RNF128

(term hierarchy)
EC

2.3.2.27
InterPro Domains

IPR003137 PA domain

IPR046450 PA domain superfamily

IPR013083 Zinc finger, RING/FYVE/PHD-type

IPR001841 Zinc finger, RING-type
GlyGen

Q9D304 3 sites, 2 N-linked glycans (2 sites)

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All nucleic 96

cDNA 93

Primer pair 1

Other 2

Microarray probesets 4

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MGI:2147939

Summaries

All 67

Developmental Gene Expression 11

Gene Ontology 8

Phenotypes 21
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnf128:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162157	ChrX:138463951-138463963 (+)	-132 bp
Tssr162158	ChrX:138464067-138464088 (+)	-11 bp
Tssr162159	ChrX:138464444-138464495 (+)	381 bp
Tssr162160	ChrX:138510958-138510987 (+)	46,884 bp
Tssr162161	ChrX:138511345-138511349 (+)	47,258 bp
Tssr162162	ChrX:138511361-138511381 (+)	47,282 bp
Tssr5685	ChrX:138511409-138511421 (+)	47,326 bp
Tssr162163	ChrX:138518133-138518144 (+)	54,050 bp
Tssr162164	ChrX:138519273-138519281 (+)	55,188 bp
Tssr162165	ChrX:138522253-138522270 (+)	58,173 bp
Tssr162166	ChrX:138552448-138552467 (+)	88,369 bp
Tssr162167	ChrX:138566169-138566181 (+)	102,086 bp
Tssr162168	ChrX:138572521-138572536 (+)	108,440 bp
Tssr162169	ChrX:138572600-138572611 (+)	108,517 bp
Tssr162170	ChrX:138572670-138572682 (+)	108,587 bp
Tssr162171	ChrX:138572759-138572774 (+)	108,678 bp
Tssr162172	ChrX:138572779-138572800 (+)	108,701 bp
Tssr162173	ChrX:138572857-138572866 (+)	108,773 bp
Tssr162174	ChrX:138572871-138572903 (+)	108,798 bp
Tssr162175	ChrX:138572939-138572954 (+)	108,858 bp
Tssr162176	ChrX:138573018-138573045 (+)	108,943 bp
Tssr162177	ChrX:138573096-138573110 (+)	109,014 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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