About   Help   FAQ
Wwp2 Gene Detail
Summary
  • Symbol
    Wwp2
  • Name
    WW domain containing E3 ubiquitin protein ligase 2
  • Synonyms
    1300010O06Rik, AIP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914144
    NCBI Gene: 66894
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:108162997-108285227 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 54.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2727 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914144
 protein coding gene Chr8:108162966-108285922 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034102
 protein coding gene Chr8:109896970-110031221 (+)
A/J MGP_AJ_G0034082
 protein coding gene Chr8:105469098-105593614 (+)
AKR/J MGP_AKRJ_G0034008
 protein coding gene Chr8:108545624-108671578 (+)
BALB/cJ MGP_BALBcJ_G0034075
 protein coding gene Chr8:105679247-105803933 (+)
C3H/HeJ MGP_C3HHeJ_G0033787
 protein coding gene Chr8:109274507-109404813 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034595
 protein coding gene Chr8:113877744-114012069 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031537
 protein coding gene Chr8:98571543-98689571 (+)
CAST/EiJ MGP_CASTEiJ_G0033114
 protein coding gene Chr8:108822185-108946612 (+)
CBA/J MGP_CBAJ_G0033760
 protein coding gene Chr8:117587571-117717406 (+)
DBA/2J MGP_DBA2J_G0033915
 protein coding gene Chr8:104797845-104923477 (+)
FVB/NJ MGP_FVBNJ_G0033860
 protein coding gene Chr8:103742541-103868890 (+)
LP/J MGP_LPJ_G0034006
 protein coding gene Chr8:110082327-110218197 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033905
 protein coding gene Chr8:120724075-120854239 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034613
 protein coding gene Chr8:108490502-108618902 (+)
PWK/PhJ MGP_PWKPhJ_G0032816
 protein coding gene Chr8:104224419-104351934 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032655
 protein coding gene Chr8:107209256-107342802 (+)
WSB/EiJ MGP_WSBEiJ_G0033229
 protein coding gene Chr8:109202139-109329066 (+)



Homology
more
  • Human Ortholog
    WWP2, WW domain containing E3 ubiquitin protein ligase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    WWP2, WW domain containing E3 ubiquitin protein ligase 2
  • Synonyms
    AIP2, WWp2-like
  • Links
    NCBI Gene ID: 11060
    neXtProt AC: NX_O00308
    UniProt: O00308

  • Chr Location
    16q22.1; chr16:69762328-69941741 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit decreased body size, domed skull, short snout, twisted snout and overgrown mandibular incisors. Mice homozygous for a different knock-out allele exhibit increased sensitivity to pIpC-treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1057
  • Tissues
    50
  • cDNA Data
    182
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031930 Ensembl Gene Model | MGI Sequence Detail 122231 C57BL/6J ±  kb
    transcript ENSMUST00000166615 Ensembl | MGI Sequence Detail 4314 Not Applicable  
    polypeptide ENSMUSP00000132224 Ensembl | MGI Sequence Detail 870 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 182
      cDNA 182

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2142444, MGI:2142806
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 18
    • Earliest
      J:63602 Huang K, et al., A HECT domain ubiquitin ligase closely related to the mammalian protein WWP1 is essential for Caenorhabditis elegans embryogenesis. Gene. 2000 Jul 11;252(1-2):137-45
    • Latest
      J:350067 Chen H, et al., The E3 ubiquitin ligase WWP2 regulates pro-fibrogenic monocyte infiltration and activity in heart fibrosis. Nat Commun. 2022 Nov 30;13(1):7375
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory