Rnpepl1 MGI Mouse Gene Detail - MGI:1914170 - arginyl aminopeptidase (aminopeptidase B)-like 1

Symbol

Rnpepl1
Name

arginyl aminopeptidase (aminopeptidase B)-like 1
Synonyms

1110014H17Rik

Feature Type

protein coding gene
IDs

MGI:1914170
NCBI Gene: 108657
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr1:92837697-92848307 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 46.60 cM
Mapping Data

2 experiments

SNPs within 2kb

295 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914170	protein coding gene	Chr1:92837697-92852106 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016329	protein coding gene	Chr1:94516020-94531319 (+)
A/J	MGP_AJ_G0016310	protein coding gene	Chr1:91130778-91144379 (+)
AKR/J	MGP_AKRJ_G0016271	protein coding gene	Chr1:93820678-93834279 (+)
BALB/cJ	MGP_BALBcJ_G0016266	protein coding gene	Chr1:91301458-91315059 (+)
C3H/HeJ	MGP_C3HHeJ_G0016095	protein coding gene	Chr1:94071209-94084799 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016725	protein coding gene	Chr1:98111972-98125578 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014443	protein coding gene	Chr1:85378308-85391921 (+)
CAST/EiJ	MGP_CASTEiJ_G0015678	protein coding gene	Chr1:93394653-93412091 (+)
CBA/J	MGP_CBAJ_G0016069	protein coding gene	Chr1:101283378-101296968 (+)
DBA/2J	MGP_DBA2J_G0016174	protein coding gene	Chr1:90327451-90341113 (+)
FVB/NJ	MGP_FVBNJ_G0016173	protein coding gene	Chr1:89395319-89408926 (+)
LP/J	MGP_LPJ_G0016245	protein coding gene	Chr1:95698504-95712121 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016198	protein coding gene	Chr1:104416659-104430260 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016764	protein coding gene	Chr1:93843101-93856697 (+)
PWK/PhJ	MGP_PWKPhJ_G0015463	protein coding gene	Chr1:89761169-89776858 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015247	protein coding gene	Chr1:92782088-92797654 (+)
WSB/EiJ	MGP_WSBEiJ_G0015738	protein coding gene	Chr1:93649086-93662718 (+)

Human Ortholog

RNPEPL1, arginyl aminopeptidase like 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RNPEPL1, arginyl aminopeptidase like 1
Links

HGNC:10079

NCBI Gene ID: 57140

neXtProt AC: NX_Q9HAU8

UniProt: Q9HAU8
Chr Location

2q37.3; chr2:240565804-240581372 (+) GRCh38

MGI Vertebrate Homology

Rnpepl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RNPEPL1
Gene Tree

Rnpepl1

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Genomic Mutations

2 involving Rnpepl1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

749
Tissues

29
cDNA Data

97
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rnpepl1

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All Sequences

84
RefSeq

10
UniProt

7
CCDS

CCDS15180.2

Ensembl

ENSMUSG00000026269 (Evidence)
NCBI Gene

108657

			Length	Strain/Species	Flank
genomic	108657	NCBI Gene Model \| MGI Sequence Detail	10611	C57BL/6J	± kb
transcript	NM_181405	RefSeq \| MGI Sequence Detail	3056	C57BL/6
polypeptide	G5E872	UniProt \| EBI \| MGI Sequence Detail	720	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000014148 aminopeptidase RNPEPL1

(term hierarchy)
EC

3.4.11.-, 3.4.11.18
InterPro Domains

IPR034015 Aminopeptidase, leukotriene A4 hydrolase-like

IPR045357 Aminopeptidase N-like , N-terminal domain

IPR042097 Aminopeptidase N-like , N-terminal domain superfamliy

IPR016024 Armadillo-type fold

IPR049980 Leukotriene A4 hydrolase-like, catalytic domain

IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase

IPR015211 Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal

IPR038502 Peptidase M1, LTA-4 hydrolase/aminopeptidase, C-terminal domain superfamily

IPR014782 Peptidase M1, membrane alanine aminopeptidase

IPR027268 Peptidase M4/M1, CTD superfamily

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All nucleic 97

cDNA 97

Microarray probesets 3

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MGI:2138375

Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 7
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Rnpepl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8141	Chr1:92838334-92838359 (+)	650 bp
Tssr8142	Chr1:92838362-92838387 (+)	678 bp
Tssr8143	Chr1:92838480-92838491 (+)	789 bp
Tssr8144	Chr1:92838527-92838556 (+)	845 bp
Tssr8145	Chr1:92838623-92838634 (+)	932 bp
Tssr8146	Chr1:92838738-92838749 (+)	1,047 bp
Tssr8147	Chr1:92839767-92839785 (+)	2,079 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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