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Fank1 Gene Detail
Summary
  • Symbol
    Fank1
  • Name
    fibronectin type 3 and ankyrin repeat domains 1
  • Synonyms
    1700007B22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914180
    NCBI Gene: 66930
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:133378594-133483261 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 77.42 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914180
 protein coding gene Chr7:133378590-133483261 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033126
 protein coding gene Chr7:138538137-138646131 (+)
A/J MGP_AJ_G0033108
 protein coding gene Chr7:134699484-134800256 (+)
AKR/J MGP_AKRJ_G0033040
 protein coding gene Chr7:138305547-138412037 (+)
BALB/cJ MGP_BALBcJ_G0033109
 protein coding gene Chr7:134408195-134516721 (+)
C3H/HeJ MGP_C3HHeJ_G0032823
 protein coding gene Chr7:138144139-138258443 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033620
 protein coding gene Chr7:143797453-143915964 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030591
 protein coding gene Chr7:135964791-136072912 (+)
CAST/EiJ MGP_CASTEiJ_G0032153
 protein coding gene Chr7:130049065-130171355 (+)
CBA/J MGP_CBAJ_G0032796
 protein coding gene Chr7:148650205-148760754 (+)
DBA/2J MGP_DBA2J_G0032948
 protein coding gene Chr7:132720402-132827834 (+)
FVB/NJ MGP_FVBNJ_G0032901
 protein coding gene Chr7:132555136-132662528 (+)
LP/J MGP_LPJ_G0033042
 protein coding gene Chr7:140062131-140175888 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032933
 protein coding gene Chr7:149549120-149664123 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033640
 protein coding gene Chr7:137312172-137431249 (+)
PWK/PhJ MGP_PWKPhJ_G0031859
 protein coding gene Chr7:125732911-125847031 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031705
 protein coding gene Chr7:124083688-124202125 (+)
WSB/EiJ MGP_WSBEiJ_G0032264
 protein coding gene Chr7:138190286-138306877 (+)



Homology
more
  • Human Ortholog
    FANK1, fibronectin type III and ankyrin repeat domains 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FANK1, fibronectin type III and ankyrin repeat domains 1
  • Synonyms
    HSD13
  • Links
    NCBI Gene ID: 92565
    neXtProt AC: NX_Q8TC84
    UniProt: Q8TC84

  • Chr Location
    10q26.2; chr10:125896564-126009592 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Mice homozygous for a knock-out allele are viable and fertile; males show normal spermatogenesis with no detectable alterations in sperm morphology, count and motility or number of apoptotic cells in testes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    738
  • Tissues
    18
  • cDNA Data
    24
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66930 NCBI Gene Model | MGI Sequence Detail 104668 C57BL/6J ±  kb
transcript NM_025850 RefSeq | MGI Sequence Detail 2000 C57BL/6  
polypeptide Q9DAM9 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 25
    cDNA 24
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:2142056
References
more
  • Summaries
    All 31
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:278620 Zhang J, et al., Normal spermatogenesis in Fank1 (fibronectin type 3 and ankyrin repeat domains 1) mutant mice. PeerJ. 2019;7:e6827
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory