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Cir1 Gene Detail
Summary
  • Symbol
    Cir1
  • Name
    corepressor interacting with RBPJ, 1
  • Synonyms
    1700023B02Rik, 2810021A19Rik, CIR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914185
    NCBI Gene: 66935
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:73113445-73142922 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.54 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    718 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914185
 protein coding gene Chr2:73113445-73143045 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025835
 protein coding gene Chr2:73574961-73581608 (-)
A/J MGP_AJ_G0025813
 protein coding gene Chr2:70668057-70694121 (-)
AKR/J MGP_AKRJ_G0025781
 protein coding gene Chr2:72602649-72637617 (-)
BALB/cJ MGP_BALBcJ_G0025807
 protein coding gene Chr2:70852120-70884334 (-)
C3H/HeJ MGP_C3HHeJ_G0025567
 protein coding gene Chr2:72796417-72822997 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026254
 protein coding gene Chr2:75745020-75774610 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023657
 protein coding gene Chr2:67866486-67896466 (-)
CAST/EiJ MGP_CASTEiJ_G0025031
 protein coding gene Chr2:73079013-73085638 (-)
CBA/J MGP_CBAJ_G0025548
 protein coding gene Chr2:78515760-78545463 (-)
DBA/2J MGP_DBA2J_G0025679
 protein coding gene Chr2:70261625-70292869 (-)
FVB/NJ MGP_FVBNJ_G0025641
 protein coding gene Chr2:69698949-69705583 (-)
LP/J MGP_LPJ_G0025767
 protein coding gene Chr2:73429594-73458612 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025672
 protein coding gene Chr2:80446679-80479013 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026311
 protein coding gene Chr2:72690163-72718851 (-)
PWK/PhJ MGP_PWKPhJ_G0024772
 protein coding gene Chr2:70177516-70212323 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024580
 protein coding gene Chr2:72925084-72956004 (-)
WSB/EiJ MGP_WSBEiJ_G0025099
 protein coding gene Chr2:73161672-73168361 (-)



Homology
more
  • Human Ortholog
    CIR1, corepressor interacting with RBPJ, CIR1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CIR1, corepressor interacting with RBPJ, CIR1
  • Synonyms
    CIR, THE1B/CIR1
  • Links
    NCBI Gene ID: 9541
    neXtProt AC: NX_Q86X95
    UniProt: Q86X95

  • Chr Location
    2q31.1; chr2:174348022-174395712 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a hypocellular placenta, abnormal placental labyrinth vasculature morphology, and complete preweaning lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    760
  • Tissues
    21
  • cDNA Data
    12
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66935 NCBI Gene Model | MGI Sequence Detail 29478 C57BL/6J ±  kb
    transcript NM_025854 RefSeq | MGI Sequence Detail 2702 C57BL/6  
    polypeptide Q9DA19 UniProt | EBI | MGI Sequence Detail 450 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1922067
    References
    more
    • Summaries
      All 58
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 26
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory