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Ddx18 Gene Detail
Summary
  • Symbol
    Ddx18
  • Name
    DEAD box helicase 18
  • Synonyms
    2310005B10Rik, DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914192
    NCBI Gene: 66942
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:121481564-121495709 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.98 cM, cytoband E2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    519 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914192
 protein coding gene Chr1:121481564-121495718 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016412
 protein coding gene Chr1:124394760-124408598 (-)
A/J MGP_AJ_G0016395
 protein coding gene Chr1:119922994-119937118 (-)
AKR/J MGP_AKRJ_G0016360
 protein coding gene Chr1:123438910-123460288 (-)
BALB/cJ MGP_BALBcJ_G0016355
 protein coding gene Chr1:120204312-120218547 (-)
C3H/HeJ MGP_C3HHeJ_G0016181
 protein coding gene Chr1:123615968-123632613 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016816
 protein coding gene Chr1:129139040-129156846 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014529
 protein coding gene Chr1:113546828-113560420 (-)
CAST/EiJ MGP_CASTEiJ_G0015762
 protein coding gene Chr1:122440904-122455085 (-)
CBA/J MGP_CBAJ_G0016154
 protein coding gene Chr1:133595313-133610266 (-)
DBA/2J MGP_DBA2J_G0016260
 protein coding gene Chr1:118945655-118959799 (-)
FVB/NJ MGP_FVBNJ_G0016259
 protein coding gene Chr1:117709354-117725459 (-)
LP/J MGP_LPJ_G0016331
 protein coding gene Chr1:125743236-125761404 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016284
 protein coding gene Chr1:139273638-139290953 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016852
 protein coding gene Chr1:123200475-123214619 (-)
PWK/PhJ MGP_PWKPhJ_G0015548
 protein coding gene Chr1:117956496-117971763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015336
 protein coding gene Chr1:122108483-122121771 (-)
WSB/EiJ MGP_WSBEiJ_G0015824
 protein coding gene Chr1:123078624-123097497 (-)



Homology
more
  • Human Ortholog
    DDX18, DEAD-box helicase 18
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDX18, DEAD-box helicase 18
  • Synonyms
    Has1, MrDb
  • Links
    NCBI Gene ID: 8886
    neXtProt AC: NX_Q9NVP1
    UniProt: Q9NVP1

  • Chr Location
    2q14.1; chr2:117814691-117832377 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit embryonic growth arrest and complete lethality before implantation. Mice homozygous for a null allele arrest at the morula stage, fail to form blastoceles, and show loss of pluripotency in early development. Mice homozygous for a different null allele show failure of morula compaction. In vitro, blastocysts fail to hatch from the zona pellucida and die after 3 days in culture.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    97
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66942 NCBI Gene Model | MGI Sequence Detail 14146 C57BL/6J ±  kb
    transcript NM_025860 RefSeq | MGI Sequence Detail 2249 C57BL/6  
    polypeptide Q8K363 UniProt | EBI | MGI Sequence Detail 660 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000006356 ATP-dependent RNA helicase DDX18
      (term hierarchy)
    • EC
      3.6.4.13
    • InterPro Domains
      IPR000629 ATP-dependent RNA helicase DEAD-box, conserved site
      IPR044773 DDX18/Has1, DEAD-box helicase domain
      IPR011545 DEAD/DEAH box helicase domain
      IPR025313 Domain of unknown function DUF4217
      IPR001650 Helicase, C-terminal domain-like
      IPR014001 Helicase superfamily 1/2, ATP-binding domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    • GlyGen
      Q8K363 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 97
      cDNA 97

      Microarray probesets 6
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:287559 Zhang H, et al., DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation. Cell Rep. 2020 Jan 7;30(1):81-97.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory