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Tmx2 Gene Detail
Summary
  • Symbol
    Tmx2
  • Name
    thioredoxin-related transmembrane protein 2
  • Synonyms
    2310042M24Rik, Txndc14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914208
    NCBI Gene: 66958
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84501655-84509172 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    193 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914208
 protein coding gene Chr2:84501655-84509484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025904
 protein coding gene Chr2:85353850-85360756 (-)
A/J MGP_AJ_G0025878
 protein coding gene Chr2:82052583-82064187 (-)
AKR/J MGP_AKRJ_G0025848
 protein coding gene Chr2:84167412-84174264 (-)
BALB/cJ MGP_BALBcJ_G0025875
 protein coding gene Chr2:82187120-82195894 (-)
C3H/HeJ MGP_C3HHeJ_G0025634
 protein coding gene Chr2:84414085-84421678 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026321
 protein coding gene Chr2:88003266-88011462 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023723
 protein coding gene Chr2:78881960-78889833 (-)
CAST/EiJ MGP_CASTEiJ_G0025095
 protein coding gene Chr2:84935110-84942920 (-)
CBA/J MGP_CBAJ_G0025615
 protein coding gene Chr2:91150426-91158227 (-)
DBA/2J MGP_DBA2J_G0025746
 protein coding gene Chr2:81594082-81602627 (-)
FVB/NJ MGP_FVBNJ_G0025709
 protein coding gene Chr2:80839842-80853807 (-)
LP/J MGP_LPJ_G0025834
 protein coding gene Chr2:85157209-85164075 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025739
 protein coding gene Chr2:93470177-93478000 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026377
 protein coding gene Chr2:84395780-84403863 (-)
PWK/PhJ MGP_PWKPhJ_G0024839
 protein coding gene Chr2:81429749-81440245 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024643
 protein coding gene Chr2:84547672-84555562 (-)
WSB/EiJ MGP_WSBEiJ_G0025165
 protein coding gene Chr2:85076736-85083608 (-)



Homology
more
  • Human Ortholog
    TMX2, thioredoxin related transmembrane protein 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMX2, thioredoxin related transmembrane protein 2
  • Synonyms
    CGI-31, NEDMCMS, PDIA12, PIG26, TXNDC14
  • Links
    NCBI Gene ID: 51075
    neXtProt AC: NX_Q9Y320
    UniProt: Q9Y320

  • Chr Location
    11q12.1; chr11:57712580-57742987 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality before implantation with abnormal morula morphology, increased cell death, and failure of blastocyst formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    910
  • Tissues
    83
  • cDNA Data
    51
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66958 NCBI Gene Model | MGI Sequence Detail 7518 C57BL/6J ±  kb
transcript NM_025868 RefSeq | MGI Sequence Detail 2287 C57BL/6  
polypeptide Q9D710 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000029819 thioredoxin-related transmembrane protein 2
    (term hierarchy)
  • InterPro Domains
    IPR013766 Thioredoxin domain
    IPR036249 Thioredoxin-like superfamily
    IPR039101 Thioredoxin-related transmembrane protein 2
    IPR037463 Thioredoxin-related transmembrane protein 2, thioredoxin domain
Molecular
Reagents
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  • All nucleic 52
    cDNA 51
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:2146774
References
more
  • Summaries
    All 40
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory