Dusp26 MGI Mouse Gene Detail - MGI:1914209 - dual specificity phosphatase 26

Symbol

Dusp26
Name

dual specificity phosphatase 26
Synonyms

2310043K02Rik

Feature Type

protein coding gene
IDs

MGI:1914209
NCBI Gene: 66959
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr8:31579555-31587074 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 17.93 cM, cytoband A3
Mapping Data

3 experiments

SNPs within 2kb

419 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914209	protein coding gene	Chr8:31579499-31587075 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033512	protein coding gene	Chr8:29469970-29477521 (+)
A/J	MGP_AJ_G0033492	protein coding gene	Chr8:28312956-28320533 (+)
AKR/J	MGP_AKRJ_G0033416	protein coding gene	Chr8:29237985-29245598 (+)
BALB/cJ	MGP_BALBcJ_G0033488	protein coding gene	Chr8:28461058-28469108 (+)
C3H/HeJ	MGP_C3HHeJ_G0033202	protein coding gene	Chr8:29538533-29546146 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034004	protein coding gene	Chr8:30545265-30554711 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030954	protein coding gene	Chr8:25199018-25206511 (+)
CAST/EiJ	MGP_CASTEiJ_G0032527	protein coding gene	Chr8:28923661-28931293 (+)
CBA/J	MGP_CBAJ_G0033178	protein coding gene	Chr8:31783715-31794128 (+)
DBA/2J	MGP_DBA2J_G0033331	protein coding gene	Chr8:28313800-28322028 (+)
FVB/NJ	MGP_FVBNJ_G0033276	protein coding gene	Chr8:28033482-28040965 (+)
LP/J	MGP_LPJ_G0033421	protein coding gene	Chr8:29419803-29427326 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033318	protein coding gene	Chr8:31368304-31377406 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034023	protein coding gene	Chr8:29251855-29259399 (+)
PWK/PhJ	MGP_PWKPhJ_G0032239	protein coding gene	Chr8:27826882-27834643 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032072	protein coding gene	Chr8:28591114-28600643 (+)
WSB/EiJ	MGP_WSBEiJ_G0032643	protein coding gene	Chr8:29414911-29427877 (+)

Human Ortholog

DUSP26, dual specificity phosphatase 26

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DUSP26, dual specificity phosphatase 26
Synonyms

DSP-4, DUSP24, LDP-4, LDP4, MKP-8, MKP8, NATA1, NEAP, SKRP3
Links

HGNC:28161

NCBI Gene ID: 78986

neXtProt AC: NX_Q9BV47

UniProt: Q9BV47
Chr Location

8p12; chr8:33591330-33600023 (-) GRCh38

MGI Vertebrate Homology

Dusp26 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: DUSP26
Gene Tree

Dusp26

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Phenotype Summary

20 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a floxed allele activated in hepatocytes exhibit increased susceptibility to diet-induxed non-nonalcoholic fatty liver disease.

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All GO Annotations

40
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

861
Tissues

32
cDNA Data

23
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

4
UniProt

1
CCDS

CCDS22219.1

Ensembl

ENSMUSG00000039661 (Evidence)
NCBI Gene

66959

			Length	Strain/Species	Flank
genomic	66959	NCBI Gene Model \| MGI Sequence Detail	7520	C57BL/6J	± kb
transcript	NM_025869	RefSeq \| MGI Sequence Detail	1888	C57BL/6
polypeptide	Q9D700	UniProt \| EBI \| MGI Sequence Detail	211	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006750 dual specificity protein phosphatase 26

(term hierarchy)
EC

3.1.3.16, 3.1.3.48
InterPro Domains

IPR020405 Atypical dual specificity phosphatase, subfamily A

IPR000340 Dual specificity phosphatase, catalytic domain

IPR020422 Dual specificity protein phosphatase domain

IPR016130 Protein-tyrosine phosphatase, active site

IPR029021 Protein-tyrosine phosphatase-like

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 26

cDNA 24

Other 2

Microarray probesets 3

Summaries

All 45

Developmental Gene Expression 6

Gene Ontology 8

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Dusp26:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr76793	Chr8:31579603-31579621 (+)	57 bp
Tssr76794	Chr8:31579634-31579788 (+)	156 bp
Tssr76795	Chr8:31580175-31580188 (+)	627 bp
Tssr76796	Chr8:31581621-31581663 (+)	2,087 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24