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Psmd12 Gene Detail
Summary
  • Symbol
    Psmd12
  • Name
    proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
  • Synonyms
    1500002F15Rik, P55
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914247
    NCBI Gene: 66997
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:107370354-107388862 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 70.29 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    478 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914247
 protein coding gene Chr11:107370310-107395188 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019320
 protein coding gene Chr11:110883125-110911460 (+)
A/J MGP_AJ_G0019288
 protein coding gene Chr11:106125739-106151018 (+)
AKR/J MGP_AKRJ_G0019257
 protein coding gene Chr11:109298612-109323282 (+)
BALB/cJ MGP_BALBcJ_G0019262
 protein coding gene Chr11:106546997-106571655 (+)
C3H/HeJ MGP_C3HHeJ_G0019071
 protein coding gene Chr11:109607506-109632241 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019712
 protein coding gene Chr11:114305135-114332027 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017336
 protein coding gene Chr11:103399326-103417908 (+)
CAST/EiJ MGP_CASTEiJ_G0018624
 protein coding gene Chr11:110699249-110725852 (+)
CBA/J MGP_CBAJ_G0019040
 protein coding gene Chr11:119023208-119050266 (+)
DBA/2J MGP_DBA2J_G0019152
 protein coding gene Chr11:105604812-105629736 (+)
FVB/NJ MGP_FVBNJ_G0019143
 protein coding gene Chr11:105098286-105123391 (+)
LP/J MGP_LPJ_G0019222
 protein coding gene Chr11:111329288-111355069 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019173
 protein coding gene Chr11:118241964-118266601 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019749
 protein coding gene Chr11:109835495-109862887 (+)
PWK/PhJ MGP_PWKPhJ_G0018389
 protein coding gene Chr11:106732582-106757519 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018180
 protein coding gene Chr11:109602887-109629787 (+)
WSB/EiJ MGP_WSBEiJ_G0018675
 protein coding gene Chr11:109795851-109823226 (+)



Homology
more
  • Human Ortholog
    PSMD12, proteasome 26S subunit, non-ATPase 12
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMD12, proteasome 26S subunit, non-ATPase 12
  • Synonyms
    p55, Rpn5, STISS
  • Links
    NCBI Gene ID: 5718
    neXtProt AC: NX_O00232
    UniProt: O00232

  • Chr Location
    17q24.2; chr17:67337916-67366605 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1082
  • Tissues
    40
  • cDNA Data
    145
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66997 NCBI Gene Model | MGI Sequence Detail 18509 C57BL/6J ±  kb
transcript NM_025894 RefSeq | MGI Sequence Detail 1723 C57BL/6  
polypeptide Q9D8W5 UniProt | EBI | MGI Sequence Detail 456 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000002178 26S proteasome non-ATPase regulatory subunit 12
    (term hierarchy)
  • InterPro Domains
    IPR040134 26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4
    IPR040896 26S proteasome regulatory subunit RPN5, C-terminal domain
    IPR000717 Proteasome component (PCI) domain
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
  • GlyGen
    Q9D8W5 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 145
    cDNA 145

    Microarray probesets 3
Other
Accession IDs
less
MGI:2144193
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
  • Latest
    J:198500 Nakahara M, et al., Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Mamm Genome. 2013 Jun;24(5-6):228-39
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory