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Rbm7 Gene Detail
Summary
  • Symbol
    Rbm7
  • Name
    RNA binding motif protein 7
  • Synonyms
    1200007M24Rik, 1500011D06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914260
    NCBI Gene: 67010
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:48400001-48406599 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.43 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    213 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914260
 protein coding gene Chr9:48399997-48406630 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034761
 protein coding gene Chr9:47265078-47271696 (-)
A/J MGP_AJ_G0034742
 protein coding gene Chr9:45866551-45873161 (-)
AKR/J MGP_AKRJ_G0034670
 protein coding gene Chr9:46821472-46828090 (-)
BALB/cJ MGP_BALBcJ_G0034734
 protein coding gene Chr9:45590344-45596956 (-)
C3H/HeJ MGP_C3HHeJ_G0034444
 protein coding gene Chr9:47276511-47283158 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035254
 protein coding gene Chr9:48615668-48622447 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032167
 protein coding gene Chr9:45346005-45352486 (-)
CAST/EiJ MGP_CASTEiJ_G0033766
 protein coding gene Chr9:47194950-47201564 (-)
CBA/J MGP_CBAJ_G0034416
 protein coding gene Chr9:50326740-50333358 (-)
DBA/2J MGP_DBA2J_G0034575
 protein coding gene Chr9:45719605-45726212 (-)
FVB/NJ MGP_FVBNJ_G0034516
 protein coding gene Chr9:44974657-44981267 (-)
LP/J MGP_LPJ_G0034656
 protein coding gene Chr9:47623881-47630499 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034560
 protein coding gene Chr9:52045352-52051963 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035275
 protein coding gene Chr9:46746111-46752729 (-)
PWK/PhJ MGP_PWKPhJ_G0033471
 protein coding gene Chr9:45680359-45687159 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033306
 protein coding gene Chr9:47060807-47067664 (-)
WSB/EiJ MGP_WSBEiJ_G0033879
 protein coding gene Chr9:46794821-46801439 (-)



Homology
more
  • Human Ortholog
    RBM7, RNA binding motif protein 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RBM7, RNA binding motif protein 7
  • Links
    NCBI Gene ID: 10179
    neXtProt AC: NX_Q9Y580
    UniProt: Q9Y580

  • Chr Location
    11q23.2; chr11:114400030-114414203 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit resistance to injury with reduced fibrosis and cell death in multiple organ-specific injury models.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    85
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042396 Ensembl Gene Model | MGI Sequence Detail 6599 C57BL/6J ±  kb
    transcript ENSMUST00000170000 Ensembl | MGI Sequence Detail 1773 Not Applicable  
    polypeptide ENSMUSP00000126374 Ensembl | MGI Sequence Detail 265 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000013808 RNA-binding protein 7
      (term hierarchy)
    • InterPro Domains
      IPR052285 Nuclear exosome targeting complex subunit
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR034500 RBM7, RNA recognition motif
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    • GlyGen
      Q9CQT2 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 85

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1915055, MGI:2143231, MGI:2143331
    References
    more
    • Summaries
      All 30
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:288329 Fukushima K, et al., Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis. Immunity. 2020 Mar 17;52(3):542-556.e13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory