Riox2 MGI Mouse Gene Detail - MGI:1914264

Symbol

Riox2
Name

ribosomal oxygenase 2
Synonyms

1810047J07Rik, 2410057H13Rik, 3830408E23Rik, Mina

Feature Type

protein coding gene
IDs

MGI:1914264
NCBI Gene: 67014
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr16:59292138-59312824 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 34.83 cM
Mapping Data

2 experiments

SNPs within 2kb

642 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914264	protein coding gene	Chr16:59292116-59312895 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022930	protein coding gene	Chr16:58751317-58772159 (+)
A/J	MGP_AJ_G0022898	protein coding gene	Chr16:56270895-56291476 (+)
AKR/J	MGP_AKRJ_G0022868	protein coding gene	Chr16:57990212-58012263 (+)
BALB/cJ	MGP_BALBcJ_G0022900	protein coding gene	Chr16:56404384-56424989 (+)
C3H/HeJ	MGP_C3HHeJ_G0022662	protein coding gene	Chr16:58228207-58248727 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023348	protein coding gene	Chr16:60394101-60414700 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020851	protein coding gene	Chr16:55710400-55731817 (+)
CAST/EiJ	MGP_CASTEiJ_G0022186	protein coding gene	Chr16:58502393-58523104 (+)
CBA/J	MGP_CBAJ_G0022633	protein coding gene	Chr16:62827967-62848673 (+)
DBA/2J	MGP_DBA2J_G0022765	protein coding gene	Chr16:55966570-55988420 (+)
FVB/NJ	MGP_FVBNJ_G0022739	protein coding gene	Chr16:55678227-55699659 (+)
LP/J	MGP_LPJ_G0022834	protein coding gene	Chr16:58557531-58578083 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022758	protein coding gene	Chr16:63207949-63228799 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023364	protein coding gene	Chr16:58102323-58122879 (+)
PWK/PhJ	MGP_PWKPhJ_G0021928	protein coding gene	Chr16:56194100-56215071 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021758	protein coding gene	Chr16:57830637-57851346 (+)
WSB/EiJ	MGP_WSBEiJ_G0022232	protein coding gene	Chr16:58133963-58154607 (+)

Human Ortholog

RIOX2, ribosomal oxygenase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RIOX2, ribosomal oxygenase 2
Synonyms

JMJD10, MDIG, MINA, MINA53, NO52, ROX
Links

HGNC:19441

NCBI Gene ID: 84864

neXtProt AC: NX_Q8IUF8

UniProt: Q8IUF8
Chr Location

3q11.2; chr3:97941818-97972457 (-) GRCh38

MGI Vertebrate Homology

Riox2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RIOX2
Gene Tree

Riox2

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

4
Gene trapped

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit reduced allergic response to house dust mites.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

9
cDNA Data

12
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase riox2

ZFIN riox2

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All Sequences

57
RefSeq

6
UniProt

4
CCDS

CCDS28257.1

Ensembl

ENSMUSG00000022724 (Evidence)
NCBI Gene

67014

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022724	Ensembl Gene Model \| MGI Sequence Detail	20687	C57BL/6J	± kb
transcript	ENSMUST00000023407	Ensembl \| MGI Sequence Detail	2159	Not Applicable
polypeptide	ENSMUSP00000023407	Ensembl \| MGI Sequence Detail	465	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000029628 ribosomal oxygenase 2

(term hierarchy)
EC

1.14.11.-, 1.14.11.79
InterPro Domains

IPR039994 Histone lysine demethylase/ribosomal histidine hydroxylase NO66-like

IPR003347 JmjC domain

IPR046799 ROXA-like, winged helix

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All nucleic 13

cDNA 13

Microarray probesets 7

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MGI:1917944, MGI:1925899, MGI:2146433

Summaries

All 42

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:358973 Zhou L, et al., Mina53 demethylates histone H4 arginine 3 asymmetric dimethylation to regulate neural stem/progenitor cell identity. Nat Commun. 2024 Nov 26;15(1):10227

TSS for Riox2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr138874	Chr16:59292141-59292224 (+)	45 bp
Tssr4921	Chr16:59292226-59292238 (+)	94 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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