Tbc1d2b MGI Mouse Gene Detail - MGI:1914266 - TBC1 domain family, member 2B

Symbol

Tbc1d2b
Name

TBC1 domain family, member 2B
Synonyms

1810061M12Rik, mKIAA1055

Feature Type

protein coding gene
IDs

MGI:1914266
NCBI Gene: 67016
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr9:90084100-90152861 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 47.48 cM
Mapping Data

2 experiments

SNPs within 2kb

2171 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914266	protein coding gene	Chr9:90084080-90152861 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035122	protein coding gene	Chr9:91149642-91226928 (-)
A/J	MGP_AJ_G0035103	protein coding gene	Chr9:87992163-88061021 (-)
AKR/J	MGP_AKRJ_G0035035	protein coding gene	Chr9:90065152-90134942 (-)
BALB/cJ	MGP_BALBcJ_G0035095	protein coding gene	Chr9:87648900-87717631 (-)
C3H/HeJ	MGP_C3HHeJ_G0034806	protein coding gene	Chr9:90517053-90589652 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035616	protein coding gene	Chr9:93700037-93774763 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032519	protein coding gene	Chr9:86166483-86235710 (-)
CAST/EiJ	MGP_CASTEiJ_G0034118	protein coding gene	Chr9:90294794-90365103 (-)
CBA/J	MGP_CBAJ_G0034774	protein coding gene	Chr9:96944461-97018866 (-)
DBA/2J	MGP_DBA2J_G0034936	protein coding gene	Chr9:87540188-87609575 (-)
FVB/NJ	MGP_FVBNJ_G0034882	protein coding gene	Chr9:86566622-86635210 (-)
LP/J	MGP_LPJ_G0035015	protein coding gene	Chr9:91386072-91459684 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034923	protein coding gene	Chr9:98552268-98624373 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035636	protein coding gene	Chr9:90292783-90366004 (-)
PWK/PhJ	MGP_PWKPhJ_G0033825	protein coding gene	Chr9:87717010-87787822 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033659	protein coding gene	Chr9:90360575-90436137 (-)
WSB/EiJ	MGP_WSBEiJ_G0034238	protein coding gene	Chr9:90179552-90251546 (-)

Human Ortholog

TBC1D2B, TBC1 domain family member 2B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBC1D2B, TBC1 domain family member 2B
Synonyms

NEDSGO
Links

HGNC:29183

NCBI Gene ID: 23102

neXtProt AC: NX_Q9UPU7

UniProt: Q9UPU7
Chr Location

15q24.3-q25.1; chr15:77984036-78077724 (-) GRCh38

MGI Vertebrate Homology

Tbc1d2b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBC1D2B
Gene Tree

Tbc1d2b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Gene trapped

2
Targeted

1
Genomic Mutations

1 involving Tbc1d2b
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

824
Tissues

109
cDNA Data

18
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tbc1d2b

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All Sequences

56
RefSeq

5
UniProt

4
CCDS

CCDS23401.1

Ensembl

ENSMUSG00000037410 (Evidence)
NCBI Gene

67016

			Length	Strain/Species	Flank
genomic	67016	NCBI Gene Model \| MGI Sequence Detail	68762	C57BL/6J	± kb
transcript	NM_194334	RefSeq \| MGI Sequence Detail	5941	C57BL/6
polypeptide	Q3U0J8	UniProt \| EBI \| MGI Sequence Detail	965	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000016111 TBC1 domain family member 2B

(term hierarchy)
InterPro Domains

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR000195 Rab-GAP-TBC domain

IPR035969 Rab-GAP-TBC domain superfamily

IPR050302 Rab GTPase-activating TBC domain-containing protein

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All nucleic 18

cDNA 18

Microarray probesets 5

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MGI:2143080, MGI:2143251, MGI:2143252, MGI:2143307

Summaries

All 35

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 7
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tbc1d2b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90858	Chr9:90152765-90152852 (-)	52 bp
Tssr90857	Chr9:90137985-90137996 (-)	14,870 bp
Tssr90856	Chr9:90132582-90132616 (-)	20,262 bp
Tssr2971	Chr9:90127354-90127403 (-)	25,482 bp
Tssr2970	Chr9:90125192-90125200 (-)	27,665 bp
Tssr90855	Chr9:90125174-90125186 (-)	27,681 bp
Tssr90854	Chr9:90125166-90125173 (-)	27,691 bp
Tssr90853	Chr9:90125072-90125086 (-)	27,782 bp
Tssr2969	Chr9:90125049-90125054 (-)	27,809 bp
Tssr90852	Chr9:90120052-90120075 (-)	32,797 bp
Tssr90851	Chr9:90119669-90119670 (-)	33,191 bp
Tssr90850	Chr9:90084738-90084786 (-)	68,099 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24