Fam210b MGI Mouse Gene Detail - MGI:1914267 - family with sequence similarity 210, member B

Symbol

Fam210b
Name

family with sequence similarity 210, member B
Synonyms

2010011I20Rik

Feature Type

protein coding gene
IDs

MGI:1914267
NCBI Gene: 67017
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr2:172187485-172197669 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 94.83 cM
Mapping Data

2 experiments

SNPs within 2kb

433 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914267	protein coding gene	Chr2:172187444-172197669 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026941	protein coding gene	Chr2:178514750-178526021 (+)
A/J	MGP_AJ_G0026908	protein coding gene	Chr2:171039626-171049718 (+)
AKR/J	MGP_AKRJ_G0026879	protein coding gene	Chr2:176201106-176211201 (+)
BALB/cJ	MGP_BALBcJ_G0026917	protein coding gene	Chr2:171430424-171440474 (+)
C3H/HeJ	MGP_C3HHeJ_G0026659	protein coding gene	Chr2:176555314-176566260 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027364	protein coding gene	Chr2:183675628-183685760 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024734	protein coding gene	Chr2:164290010-164299823 (+)
CAST/EiJ	MGP_CASTEiJ_G0026117	protein coding gene	Chr2:177217604-177227691 (+)
CBA/J	MGP_CBAJ_G0026636	protein coding gene	Chr2:190528119-190541597 (+)
DBA/2J	MGP_DBA2J_G0026774	protein coding gene	Chr2:170134813-170145111 (+)
FVB/NJ	MGP_FVBNJ_G0026740	protein coding gene	Chr2:168731529-168741579 (+)
LP/J	MGP_LPJ_G0026875	protein coding gene	Chr2:178445362-178456735 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026759	protein coding gene	Chr2:193521104-193532493 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027421	protein coding gene	Chr2:176161841-176172399 (+)
PWK/PhJ	MGP_PWKPhJ_G0025854	protein coding gene	Chr2:169890324-169900792 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025654	protein coding gene	Chr2:175166145-175176285 (+)
WSB/EiJ	MGP_WSBEiJ_G0026190	protein coding gene	Chr2:177137806-177149405 (+)

Human Ortholog

FAM210B, family with sequence similarity 210 member B

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FAM210B, family with sequence similarity 210 member B
Synonyms

5A3, C20orf108, dJ1167H4.1
Links

HGNC:16102

NCBI Gene ID: 116151

neXtProt AC: NX_Q96KR6

UniProt: Q96KR6
Chr Location

20q13.2; chr20:56358974-56368663 (+) GRCh38

MGI Vertebrate Homology

Fam210b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FAM210B
Gene Tree

Fam210b

Diseases

1 with Fam210b mouse models

Human Disease

Mouse Models

systemic lupus erythematosus

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

2
Targeted

3
Incidental Mutations

APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null mutation display a low incidence of increased autoantibody levels, splenomegaly, skin ulcers, and impaired erythocyte differentiation.

less

All GO Annotations

17
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

799
Tissues

41
cDNA Data

70
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fam210b

ZFIN fam210b

less

All Sequences

50
RefSeq

4
UniProt

2
CCDS

CCDS17128.1

Ensembl

ENSMUSG00000027495 (Evidence)
NCBI Gene

67017

			Length	Strain/Species	Flank
genomic	ENSMUSG00000027495	Ensembl Gene Model \| MGI Sequence Detail	10185	C57BL/6J	± kb
transcript	ENSMUST00000028995	Ensembl \| MGI Sequence Detail	3617	Not Applicable
polypeptide	ENSMUSP00000028995	Ensembl \| MGI Sequence Detail	190	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000032757 protein FAM210B, mitochondrial

(term hierarchy)
InterPro Domains

IPR045866 Protein FAM210A/B-like

IPR009688 Protein FAM210A/B-like domain

less

All nucleic 74

cDNA 70

Primer pair 3

Other 1

Microarray probesets 8

less

MGI:2138942, MGI:2139253

Summaries

All 43

Developmental Gene Expression 9

Diseases 1

Gene Ontology 5

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:351618 Xu Y, et al., Deletion of the Mitochondrial Membrane Protein Fam210b Is Associated with the Development of Systemic Lupus Erythematosus. Int J Mol Sci. 2024 Jul 1;25(13)

TSS for Fam210b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21944	Chr2:172187499-172187510 (+)	20 bp
Tssr21945	Chr2:172187515-172187546 (+)	46 bp
Tssr21946	Chr2:172187548-172187567 (+)	73 bp
Tssr21947	Chr2:172195209-172195216 (+)	7,728 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24