Oxct1 MGI Mouse Gene Detail - MGI:1914291 - 3-oxoacid CoA transferase 1

Symbol

Oxct1
Name

3-oxoacid CoA transferase 1
Synonyms

2610008O03Rik, Scot-s

Feature Type

protein coding gene
IDs

MGI:1914291
NCBI Gene: 67041
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr15:4055910-4184826 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 1.86 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

3643 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914291	protein coding gene	Chr15:4055865-4184826 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021685	protein coding gene	Chr15:893831-1034490 (+)
A/J	MGP_AJ_G0021645	protein coding gene	Chr15:921084-1055168 (+)
AKR/J	MGP_AKRJ_G0021623	protein coding gene	Chr15:905967-1036980 (+)
BALB/cJ	MGP_BALBcJ_G0021652	protein coding gene	Chr15:881032-1015855 (+)
C3H/HeJ	MGP_C3HHeJ_G0021428	protein coding gene	Chr15:916817-1053682 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022091	protein coding gene	Chr15:980027-1126062 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019629	protein coding gene	Chr15:770148-894643 (+)
CAST/EiJ	MGP_CASTEiJ_G0020944	protein coding gene	Chr15:913218-1056629 (+)
CBA/J	MGP_CBAJ_G0021397	protein coding gene	Chr15:961771-1118401 (+)
DBA/2J	MGP_DBA2J_G0021521	protein coding gene	Chr15:894697-1025025 (+)
FVB/NJ	MGP_FVBNJ_G0021499	protein coding gene	Chr15:844117-974373 (+)
LP/J	MGP_LPJ_G0021588	protein coding gene	Chr15:875123-1007980 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021525	protein coding gene	Chr15:1016319-1163759 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022114	protein coding gene	Chr15:886977-1027370 (+)
PWK/PhJ	MGP_PWKPhJ_G0020688	protein coding gene	Chr15:902569-1046271 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020526	protein coding gene	Chr15:959466-1147149 (+)
WSB/EiJ	MGP_WSBEiJ_G0021000	protein coding gene	Chr15:874621-1014440 (+)

Human Ortholog

OXCT1, 3-oxoacid CoA-transferase 1

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

OXCT1, 3-oxoacid CoA-transferase 1
Synonyms

OXCT, SCOT
Links

HGNC:8527

NCBI Gene ID: 5019

neXtProt AC: NX_P55809

UniProt: P55809
Chr Location

5p13.1; chr5:41730065-41870425 (-) GRCh38

MGI Vertebrate Homology

Oxct1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: OXCT1
Protein SuperFamily

SCOT-t
Gene Tree

Oxct1

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Phenotype Summary

9 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Gene trapped

1
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit hyperketonemia, ketoacidosis, increased glucose oxidation in the brain, increased autophagy in the brain, and neonatal lethality.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

716
Tissues

3
cDNA Data

379
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase oxct1

ZFIN oxct1a, oxct1b

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All Sequences

66
RefSeq

2
UniProt

6
CCDS

CCDS27361.1

Ensembl

ENSMUSG00000022186 (Evidence)
NCBI Gene

67041

			Length	Strain/Species	Flank
genomic	67041	NCBI Gene Model \| MGI Sequence Detail	128917	C57BL/6J	± kb
transcript	NM_024188	RefSeq \| MGI Sequence Detail	3496	C57BL/6
polypeptide	Q9D0K2	UniProt \| EBI \| MGI Sequence Detail	520	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012095 succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial

(term hierarchy)
EC

2.8.3.5
InterPro Domains

IPR014388 3-oxoacid CoA-transferase

IPR012792 3-oxoacid CoA-transferase, subunit A

IPR012791 3-oxoacid CoA-transferase, subunit B

IPR004164 Coenzyme A transferase active site

IPR004163 Coenzyme A transferase binding site

IPR004165 Coenzyme A transferase family I

IPR037171 NagB/RpiA transferase-like
GlyGen

Q9D0K2 1 site, 1 O-linked glycan (1 site)

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All nucleic 381

cDNA 379

Primer pair 2

Microarray probesets 5

Summaries

All 46

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 13
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:346093 Ma W, et al., OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB. Mol Cell. 2024 Feb 1;84(3):538-551.e7

TSS for Oxct1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130423	Chr15:4055942-4055953 (+)	38 bp
Tssr130424	Chr15:4056038-4056049 (+)	134 bp
Tssr130425	Chr15:4056094-4056177 (+)	226 bp
Tssr130426	Chr15:4056178-4056245 (+)	302 bp
Tssr130427	Chr15:4064947-4064948 (+)	9,038 bp
Tssr130428	Chr15:4098793-4098800 (+)	42,887 bp
Tssr130429	Chr15:4098830-4098839 (+)	42,925 bp
Tssr4539	Chr15:4106650-4106652 (+)	50,741 bp
Tssr130430	Chr15:4142285-4142326 (+)	86,396 bp
Tssr4540	Chr15:4149441-4149449 (+)	93,535 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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