Higd2a MGI Mouse Gene Detail - MGI:1914294 - HIG1 domain family, member 2A

Symbol

Higd2a
Name

HIG1 domain family, member 2A
Synonyms

2010110M21Rik

Feature Type

protein coding gene
IDs

MGI:1914294
NCBI Gene: 67044
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:54738044-54738960 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 28.84 cM
Mapping Data

2 experiments

SNPs within 2kb

144 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914294	protein coding gene	Chr13:54738020-54738971 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020573	protein coding gene	Chr13:53996491-53997442 (+)
A/J	MGP_AJ_G0020527	protein coding gene	Chr13:52015213-52016164 (+)
AKR/J	MGP_AKRJ_G0020505	protein coding gene	Chr13:53543913-53544864 (+)
BALB/cJ	MGP_BALBcJ_G0020523	protein coding gene	Chr13:52247182-52248133 (+)
C3H/HeJ	MGP_C3HHeJ_G0020322	protein coding gene	Chr13:53369303-53370254 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020957	protein coding gene	Chr13:55651126-55652077 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018539	protein coding gene	Chr13:50010182-50011135 (+)
CAST/EiJ	MGP_CASTEiJ_G0019836	protein coding gene	Chr13:53448612-53449556 (+)
CBA/J	MGP_CBAJ_G0020282	protein coding gene	Chr13:57764141-57765092 (+)
DBA/2J	MGP_DBA2J_G0020405	protein coding gene	Chr13:51583793-51584744 (+)
FVB/NJ	MGP_FVBNJ_G0020384	protein coding gene	Chr13:51031628-51032579 (+)
LP/J	MGP_LPJ_G0020481	protein coding gene	Chr13:54271407-54272358 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020413	protein coding gene	Chr13:57259930-57260881 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021000	protein coding gene	Chr13:53139115-53140066 (+)
PWK/PhJ	MGP_PWKPhJ_G0019592	protein coding gene	Chr13:51569708-51571272 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019419	protein coding gene	Chr13:52054255-52055202 (+)
WSB/EiJ	MGP_WSBEiJ_G0019898	protein coding gene	Chr13:53476917-53477868 (+)

Human Ortholog

HIGD2A, HIG1 hypoxia inducible domain family member 2A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

HIGD2A, HIG1 hypoxia inducible domain family member 2A
Synonyms

HIG2A, RCF1b
Links

HGNC:28311

NCBI Gene ID: 192286

neXtProt AC: NX_Q9BW72

UniProt: Q9BW72
Chr Location

5q35.2; chr5:176388751-176389761 (+) GRCh38

Human Ortholog

HIGD2B, HIG1 hypoxia inducible domain family member 2B
Synonyms

HIGD2BP
Links

HGNC:26984

NCBI Gene ID: 123346

UniProt: Q4VC39
Chr Location

15q24.1; chr15:72675798-72686182 (-) GRCh38

MGI Vertebrate Homology

Higd2a stringent orthology
2 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: HIGD2A, HIGD2B
Gene Tree

Higd2a

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Gene trapped

1
Targeted

5
Genomic Mutations

2 involving Higd2a
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

5

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

794
Tissues

45
cDNA Data

117
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase higd2a

ZFIN higd2a

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS26532.1

Ensembl

ENSMUSG00000025868 (Evidence)
NCBI Gene

67044

			Length	Strain/Species	Flank
genomic	67044	NCBI Gene Model \| MGI Sequence Detail	917	C57BL/6J	± kb
transcript	NM_025933	RefSeq \| MGI Sequence Detail	613	C57BL/6
polypeptide	Q9CQJ1	UniProt \| EBI \| MGI Sequence Detail	106	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000029544 HIG1 domain family member 2A

(term hierarchy)
InterPro Domains

IPR007667 Hypoxia induced protein, domain

IPR050355 Mitochondrial Respiratory Supercomplex Factor 1

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All nucleic 118

cDNA 118

Microarray probesets 3

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MGI:2145173

Summaries

All 39

Developmental Gene Expression 2

Diseases 1

Gene Ontology 5

Phenotypes 12
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Higd2a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119879	Chr13:54737739-54737765 (+)	-292 bp
Tssr119880	Chr13:54738017-54738031 (+)	-20 bp
Tssr119881	Chr13:54738034-54738080 (+)	13 bp
Tssr119882	Chr13:54738566-54738582 (+)	530 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24