Nkap MGI Mouse Gene Detail - MGI:1914300

Symbol

Nkap
Name

NFKB activating protein
Synonyms

2610020O08Rik

Feature Type

protein coding gene
IDs

MGI:1914300
NCBI Gene: 67050
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

ChrX:36390448-36414399 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome X, 21.54 cM
Mapping Data

2 experiments

SNPs within 2kb

492 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914300	protein coding gene	ChrX:36390416-36414399 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0035632	protein coding gene	ChrX:32076673-32100500 (+)
A/J	MGP_AJ_G0035609	protein coding gene	ChrX:32138263-32163480 (+)
AKR/J	MGP_AKRJ_G0035542	protein coding gene	ChrX:32870094-32893891 (+)
BALB/cJ	MGP_BALBcJ_G0035602	protein coding gene	ChrX:31861599-31885558 (+)
C3H/HeJ	MGP_C3HHeJ_G0035320	protein coding gene	ChrX:32386927-32411614 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036138	protein coding gene	ChrX:32709613-32735936 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033000	protein coding gene	ChrX:30350322-30373477 (+)
CAST/EiJ	MGP_CASTEiJ_G0034610	protein coding gene	ChrX:20544982-20570117 (+)
CBA/J	MGP_CBAJ_G0035289	protein coding gene	ChrX:33574735-33605584 (+)
DBA/2J	MGP_DBA2J_G0035440	protein coding gene	ChrX:31953597-31978315 (+)
FVB/NJ	MGP_FVBNJ_G0035387	protein coding gene	ChrX:31719532-31745524 (+)
LP/J	MGP_LPJ_G0035522	protein coding gene	ChrX:32461473-32487024 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035431	protein coding gene	ChrX:34016370-34040393 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036145	protein coding gene	ChrX:32042975-32066607 (+)
PWK/PhJ	MGP_PWKPhJ_G0034312	protein coding gene	ChrX:19996163-20019622 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034153	protein coding gene	ChrX:21025632-21049788 (+)
WSB/EiJ	MGP_WSBEiJ_G0034746	protein coding gene	ChrX:31836705-31862572 (+)

Human Ortholog

NKAP, NFKB activating protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NKAP, NFKB activating protein
Synonyms

MRXSHD
Links

HGNC:29873

NCBI Gene ID: 79576

neXtProt AC: NX_Q8N5F7

UniProt: Q8N5F7
Chr Location

Xq24; chrX:119920672-119943751 (-) GRCh38

MGI Vertebrate Homology

Nkap stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NKAP
Gene Tree

Nkap

Diseases

1 with human NKAP associations

				Human Disease	Mouse Models
				syndromic X-linked intellectual disability IDs syndromic X-linked intellectual disability DOID:0060309 OMIM:PS309510

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Gene trapped

5
Targeted

1
Find Mice (IMSR)

1 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a conditional allele activated in T cells exhibit impaired T cell differentiation at the DN3 stage with increased DN3 T cells and decreased total thymocytes, single positive T cells, and double positive T cells.

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All GO Annotations

25
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

8
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nkap

ZFIN nkap

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All Sequences

41
RefSeq

2
UniProt

1
CCDS

CCDS30069.1

Ensembl

ENSMUSG00000016409 (Evidence)
NCBI Gene

67050

			Length	Strain/Species	Flank
genomic	ENSMUSG00000016409	Ensembl Gene Model \| MGI Sequence Detail	23952	C57BL/6J	± kb
transcript	ENSMUST00000016553	Ensembl \| MGI Sequence Detail	4230	Not Applicable
polypeptide	ENSMUSP00000016553	Ensembl \| MGI Sequence Detail	415	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011230 NF-kappa-B-activating protein

(term hierarchy)
InterPro Domains

IPR040466 NF-kappa-B-activating protein

IPR009269 NF-kappa-B-activating protein, C-terminal

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All nucleic 8

cDNA 8

Microarray probesets 7

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MGI:2147837, MGI:2147924, MGI:2147948

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:293523 Dash B, et al., The Interaction between NKAP and HDAC3 Is Critical for T Cell Maturation. Immunohorizons. 2019 Aug 6;3(8):352-367

TSS for Nkap:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr160760	ChrX:36390416-36390427 (+)	-26 bp
Tssr160761	ChrX:36390430-36390448 (+)	-9 bp
Tssr160762	ChrX:36390456-36390489 (+)	25 bp
Tssr160763	ChrX:36394652-36394686 (+)	4,221 bp
Tssr160764	ChrX:36407617-36407634 (+)	17,178 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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