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Ola1 Gene Detail
Summary
  • Symbol
    Ola1
  • Name
    Obg-like ATPase 1
  • Synonyms
    2510025G09Rik, 2810405J23Rik, 2810409H07Rik, Gtpbp9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914309
    NCBI Gene: 67059
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:72923145-73044791 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 43.35 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2077 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914309
 protein coding gene Chr2:72923145-73049268 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025833
 protein coding gene Chr2:73351401-73490352 (-)
A/J MGP_AJ_G0025811
 protein coding gene Chr2:70460461-70602839 (-)
AKR/J MGP_AKRJ_G0025779
 protein coding gene Chr2:72406941-72535597 (-)
BALB/cJ MGP_BALBcJ_G0025805
 protein coding gene Chr2:70659103-70786248 (-)
C3H/HeJ MGP_C3HHeJ_G0025565
 protein coding gene Chr2:72587188-72720871 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026252
 protein coding gene Chr2:75535063-75671968 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023655
 protein coding gene Chr2:67675071-67804655 (-)
CAST/EiJ MGP_CASTEiJ_G0025029
 protein coding gene Chr2:72846772-72985516 (-)
CBA/J MGP_CBAJ_G0025546
 protein coding gene Chr2:78298909-78439262 (-)
DBA/2J MGP_DBA2J_G0025677
 protein coding gene Chr2:70066627-70195737 (-)
FVB/NJ MGP_FVBNJ_G0025639
 protein coding gene Chr2:69484378-69610578 (-)
LP/J MGP_LPJ_G0025765
 protein coding gene Chr2:73229320-73362518 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025670
 protein coding gene Chr2:80242768-80378952 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026309
 protein coding gene Chr2:72485729-72618047 (-)
PWK/PhJ MGP_PWKPhJ_G0024770
 protein coding gene Chr2:69985793-70114192 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024578
 protein coding gene Chr2:72722465-72857332 (-)
WSB/EiJ MGP_WSBEiJ_G0025097
 protein coding gene Chr2:72933152-73068986 (-)



Homology
more
  • Human Ortholog
    OLA1, Obg like ATPase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OLA1, Obg like ATPase 1
  • Synonyms
    DOC45, GBP45, GTBP9, GTPBP9, PTD004
  • Links
    NCBI Gene ID: 29789
    neXtProt AC: NX_Q9NTK5
    UniProt: Q9NTK5

  • Chr Location
    2q31.1; chr2:174072447-174248599 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display partial neonatal lethality, embryonic developmental delay, delayed development of lung and liver, and reduced body size.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    112
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67059 NCBI Gene Model | MGI Sequence Detail 121647 C57BL/6J ±  kb
    transcript NM_025942 RefSeq | MGI Sequence Detail 2189 C57BL/6  
    polypeptide Q9CZ30 UniProt | EBI | MGI Sequence Detail 396 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 112
      cDNA 112

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1919980, MGI:1925605
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 28
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:347096 Yoshino Y, et al., Knockout of Brca1-interacting factor Ola1 in female mice induces tumors with estrogen suppressible centrosome amplification. Biochim Biophys Acta Mol Basis Dis. 2024 Mar 26;1870(5):167138
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory