Polr3d MGI Mouse Gene Detail - MGI:1914315 - polymerase (RNA) III (DNA directed) polypeptide D

Symbol

Polr3d
Name

polymerase (RNA) III (DNA directed) polypeptide D
Synonyms

2810426M17Rik, 44kDa, BN51T, RPC4, TSBN51

Feature Type

protein coding gene
IDs

MGI:1914315
NCBI Gene: 67065
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr14:70676197-70680887 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.32 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

192 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1914315	protein coding gene	Chr14:70676188-70680911 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021537	protein coding gene	Chr14:65090950-65095673 (-)
A/J	MGP_AJ_G0021496	protein coding gene	Chr14:63707522-63712245 (-)
AKR/J	MGP_AKRJ_G0021472	protein coding gene	Chr14:65618432-65623154 (-)
BALB/cJ	MGP_BALBcJ_G0021502	protein coding gene	Chr14:63470226-63474949 (-)
C3H/HeJ	MGP_C3HHeJ_G0021279	protein coding gene	Chr14:65334515-65339238 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0021941	protein coding gene	Chr14:68001215-68005937 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019481	protein coding gene	Chr14:61542295-61547029 (-)
CAST/EiJ	MGP_CASTEiJ_G0020796	protein coding gene	Chr14:61925100-61931151 (-)
CBA/J	MGP_CBAJ_G0021246	protein coding gene	Chr14:70141164-70145887 (-)
DBA/2J	MGP_DBA2J_G0021369	protein coding gene	Chr14:63090943-63095700 (-)
FVB/NJ	MGP_FVBNJ_G0021348	protein coding gene	Chr14:62519639-62524702 (-)
LP/J	MGP_LPJ_G0021440	protein coding gene	Chr14:66330630-66335353 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021377	protein coding gene	Chr14:69031571-69036324 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021965	protein coding gene	Chr14:64880071-64884794 (-)
PWK/PhJ	MGP_PWKPhJ_G0020540	protein coding gene	Chr14:59857930-59862682 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020373	protein coding gene	Chr14:60806131-60810835 (-)
WSB/EiJ	MGP_WSBEiJ_G0020849	protein coding gene	Chr14:65187680-65192401 (-)

Human Ortholog

POLR3D, RNA polymerase III subunit D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

POLR3D, RNA polymerase III subunit D
Synonyms

BN51T, C53, RPC4, RPC53, TSBN51
Links

HGNC:1080

NCBI Gene ID: 661

neXtProt AC: NX_P05423

UniProt: P05423
Chr Location

8p21.3; chr8:22245133-22254601 (+) GRCh38

MGI Vertebrate Homology

Polr3d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: POLR3D
Gene Tree

Polr3d

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

1 involving Polr3d
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

18
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

810
Tissues

104
cDNA Data

71
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase polr3d

ZFIN polr3d

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All Sequences

47
RefSeq

6
UniProt

1
CCDS

CCDS27253.1

Ensembl

ENSMUSG00000000776 (Evidence)
NCBI Gene

67065

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000776	Ensembl Gene Model \| MGI Sequence Detail	4691	C57BL/6J	± kb
transcript	ENSMUST00000000793	Ensembl \| MGI Sequence Detail	2016	Not Applicable
polypeptide	ENSMUSP00000000793	Ensembl \| MGI Sequence Detail	398	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000013003 DNA-directed RNA polymerase III subunit RPC4

(term hierarchy)
InterPro Domains

IPR007811 DNA-directed RNA polymerase III subunit RPC4

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All nucleic 71

cDNA 71

Microarray probesets 5

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MGI:2145623, MGI:2145815

Summaries

All 38

Developmental Gene Expression 2

Gene Ontology 9

Phenotypes 6
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Polr3d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129590	Chr14:70680882-70680916 (-)	-12 bp
Tssr129589	Chr14:70680853-70680876 (-)	22 bp
Tssr129588	Chr14:70680836-70680847 (-)	45 bp
Tssr129587	Chr14:70680659-70680678 (-)	218 bp
Tssr129586	Chr14:70680598-70680617 (-)	279 bp
Tssr129585	Chr14:70680566-70680593 (-)	307 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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